Results 71 to 80 of about 6,364 (304)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Rotor Dynamic Characteristics Supported by Multi-Pad Bump Foil Gas Bearings

Lubricants
Bump foil gas bearings (BFGBs) play an important role in high-speed turbomachinery. However, most studies on the dynamic characteristics of BFGBs focus on a one-pad structure composed of a bump foil and a top foil. This paper considers the multi-pad foil
Lei Zhao, Hongyang Hu, Changlin Li, Jingquan Zhao   +3 more
doaj   +1 more source

Performance analysis of the bump beams made of High Strength Steel and Carbon Fiber reinforce plastics

MATEC Web of Conferences, 2018
Lightweight and safe are the key research directions of the automobile industry. Bump beam is an important part of the car safety protection and it’s lightweight design has drawn much attention. In this paper, the static strength and the low-speed impact
Yao Yi, Yuan Quan, Fu Sihuan
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Revolution-bump mapping with texture function adjustment according to the geometry of the revolved object

Journal of Graphic Engineering and Design
Nowadays, 3D computer graphics are firmly anchored in our daily lives, extending across a multitude of distinct fields. Although each field follows its specific objectives, two major objectives are taken into consideration: realism and rendering speed ...
Anouar Ragragui, Adnane Ouazzani Chahdi, Amina Arbah, Hicham El Moubtahij, Akram Halli, Khalid Satori   +5 more
doaj   +1 more source

Electronic speed bump for vehicles with autonomous driving capabilities

, 2019
Successfully and smoothly navigating a speed bump requires a vehicle to slow down to an appropriate speed, pass over the bump, and speed up afterward. Such slow-down and speed-up increases the wear and tear of the vehicle suspension and chassis, reduces ...
Alakuijala, Jyrki, Hancock, Michael
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pemanfaatan Tanjakan Jalan Raya (Speed Bump)Sebagai Energi Listrik Alternatif [PDF]

, 2017
Electricity is an energy that has an important role in human life. PT. PLN as a provider of electrical energy is currently experiencing difficulties to meet the needs of national electrical energy.
Azmi, Fakhrizal
core   +2 more sources

DYNAMIC ANALYSIS OF NON-PNEUMATIC TIRES WITH HONEYCOMB SPOKES ON SPEED BUMPS

Rekayasa Mesin
The Non-Pneumatic Tire (NPT) has rapidly developed as an alternative to the Pneumatic Tire since it was created by Michelin in 2005. This research aims to investigate the influence of load and speed on the stress experienced by honeycomb-structured ...
Rachmat Sriwijaya, Fakhri Ghiffari, Zahran Ra’if, Burhani Wijaya   +3 more
doaj   +1 more source