Results 101 to 110 of about 59,744 (294)
TRIP WIRES AND SPEED BUMPS: MANAGING FINANCIAL RISKS AND REDUCING THE POTENTIAL FOR FINANCIAL CRISES IN DEVELOPING ECONOMIES [PDF]
This paper investigates the shortcomings of the “early warning systems” (EWS) that are currently being promoted with such vigour in the multilateral and academic community. It then advocates an integrated “trip wire-speed bump” regime to reduce financial
Ilene GRABEL
core
QuaRel: A Dataset and Models for Answering Questions about Qualitative Relationships
, 2018 Many natural language questions require recognizing and reasoning with qualitative relationships (e.g., in science, economics, and medicine), but are challenging to answer with corpus-based methods.
Clark, Peter +4 more
core +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
DYNAMIC ANALYSIS OF NON-PNEUMATIC TIRES WITH HONEYCOMB SPOKES ON SPEED BUMPS
Rekayasa MesinThe Non-Pneumatic Tire (NPT) has rapidly developed as an alternative to the Pneumatic Tire since it was created by Michelin in 2005. This research aims to investigate the influence of load and speed on the stress experienced by honeycomb-structured ...
Rachmat Sriwijaya +3 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
New Paradigms For Asteroid Formation
, 2015 Asteroids and meteorites provide key evidence on the formation of planetesimals in the Solar System. Asteroids are traditionally thought to form in a bottom-up process by coagulation within a population of initially km-scale planetesimals.
Cuzzi, Jeffrey N. +4 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Coarse-grained dynamics of an activity bump in a neural field model
, 2006 We study a stochastic nonlocal PDE, arising in the context of modelling spatially distributed neural activity, which is capable of sustaining stationary and moving spatially-localized ``activity bumps''.
Baker C +12 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source