Results 91 to 100 of about 59,960 (292)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Fast Cross-Validation via Sequential Testing [PDF]

, 2015
With the increasing size of today's data sets, finding the right parameter configuration in model selection via cross-validation can be an extremely time-consuming task.
Braun, Mikio, Krueger, Tammo, Panknin, Danny   +2 more
core  

Sculpting quasi one-dimensional Bose-Einstein condensate to generate calibrated matter-waves

, 2016
We explore theoretically how to tune the dynamics of a quasi one-dimensional harmonically trapped Bose-Einstein condensate (BEC) due to an additional red- and blue-detuned Hermite-Gaussian dimple trap (HGdT).
Akram, Javed, Pelster, Axel
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Design of main linac emittance tuning bumps for the Compact Linear Collider and the International Linear Collider

Physical Review Special Topics. Accelerators and Beams, 2008
The installation of elements in the main linac of future linear colliders can only be done with a limited precision. The inevitable misalignments lead to unacceptable emittance growth.
Peder Eliasson, Daniel Schulte
doaj   +1 more source

Reducing reflections from mesh refinement interfaces in numerical relativity

, 2005
Full interpretation of data from gravitational wave observations will require accurate numerical simulations of source systems, particularly binary black hole mergers.
B. Schutz, G. Gonzalez, James R. van Meter, John G. Baker, T. Nakamura   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fabrication and mechanical behavior of (111) oriented nanotwinned Cu-bumps toward Cu-Cu bonding for 3D packaging

Materials & Design
Realizing Cu-Cu bonding with (111)-oriented nanotwinned Cu pillar bumps (Cu-bumps) is a key route to overcoming the limitations of Moore’s Law and enabling high-density 3D packaging.
Huijun Cao, Yiwei Cui, Yuncong Wang, Qinghua Li, Yichen Zhu, Zihao Long, Zhihao Zhang   +6 more
doaj   +1 more source