Results 71 to 80 of about 4,965 (256)

Improvement of Dynamic Characteristics of Purpose-Built Vehicles Using Semi-Active Suspension System

Sensors
The diversification of mobility into services such as smart stores and conference rooms has accelerated the development of purpose-built vehicles (PBVs)—vehicles designed for specific purposes that utilize an extended electric vehicle chassis and ...
Minyoung Kim, Chunhwan Lee
doaj   +1 more source

Design of main linac emittance tuning bumps for the Compact Linear Collider and the International Linear Collider

Physical Review Special Topics. Accelerators and Beams, 2008
The installation of elements in the main linac of future linear colliders can only be done with a limited precision. The inevitable misalignments lead to unacceptable emittance growth.
Peder Eliasson, Daniel Schulte
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Fabrication and mechanical behavior of (111) oriented nanotwinned Cu-bumps toward Cu-Cu bonding for 3D packaging

Materials & Design
Realizing Cu-Cu bonding with (111)-oriented nanotwinned Cu pillar bumps (Cu-bumps) is a key route to overcoming the limitations of Moore’s Law and enabling high-density 3D packaging.
Huijun Cao, Yiwei Cui, Yuncong Wang, Qinghua Li, Yichen Zhu, Zihao Long, Zhihao Zhang   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DYNAMIC ANALYSIS OF NON-PNEUMATIC TIRES WITH HONEYCOMB SPOKES ON SPEED BUMPS

Rekayasa Mesin
The Non-Pneumatic Tire (NPT) has rapidly developed as an alternative to the Pneumatic Tire since it was created by Michelin in 2005. This research aims to investigate the influence of load and speed on the stress experienced by honeycomb-structured ...
Rachmat Sriwijaya, Fakhri Ghiffari, Zahran Ra’if, Burhani Wijaya   +3 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source