Results 41 to 50 of about 4,903 (212)

Improved Vehicle Vibration Control through Optimization of Suspension Parameters Using the Response Surface Method and a Non-Linear Programming with a Quadratic Lagrangian Algorithm

Actuators, 2023
Vibration-control techniques generally fall into two categories: passive methods that optimize the structure of the suspension to absorb any impact from the ground, and active methods that directly control the vertical force of the suspension by ...
Wei Dai, Liuqing He, Yongjun Pan, Sheng-Peng Zhang, Liang Hou   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimizing Water Flow With Cavitation on the NACA 0009 Hydrofoil Inspired by the Mako Shark Bumps

International Journal of Aerospace Engineering
The numerical investigation of the water flow with partial cavitation around the NACA 0009 hydrofoil with bumps inspired by the mako shark (biomimicry) was performed. The simulation was done by ANSYS Fluent software for cavitation numbers of 1 and 1.5 at
Mohammad Asldar, Mahmoud Pasandidehfard, Mohammad Hossein MoghimiEsfandabadi   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Bump Modeling and Vehicle Vertical Dynamics Prediction

Advances in Mechanical Engineering, 2014
During a journey, motor vehicles are subjected to different types of irregularities in the pavement. Some of these irregularities are introduced for a specific purpose over a stretch of road to slow down the vehicle at certain road points.
Daniel Garcia-Pozuelo, Antonio Gauchia, Ester Olmeda, Vicente Diaz   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Speed Bump System Based on Vehicle Speed Using Adaptive Background Subtraction with Haar Cascade Classifier

Sistemasi: Jurnal Sistem Informasi
Driving at high speed and recklessly is the main cause of traffic accidents. In several places speed bumps are installed as a medium to warn drivers to slow down the speed of the vehicle, but the installation of speed bumps in several places has become a
Muhammad Zulfikri, Wirajaya Kusuma, Sirojul Hadi, Husain Husain, Rifqi Hammad, Lalu Zazuli Azhar Mardedi   +5 more
doaj   +1 more source