Results 41 to 50 of about 22,911 (237)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
High Speed Hill Climbing Algorithm for Portfolio Optimization
Tanzania Journal of Science, 2021 Portfolio can be defined as a collection of investments. Portfolio optimization usually is about maximizing expected return and/or minimising risk of a portfolio. The mean-variance model makes simplifying assumptions to solve portfolio optimization problem. Presence of realistic constraints leads to a significant different and complex problem.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Dynamics of Stride Interval Characteristics during Continuous Stairmill Climbing
Frontiers in Physiology, 2017 It has been shown that statistical persistence in stride intervals characteristics exist during walking, running and cycling and were speed-dependent among healthy young adults.
Peter C. Raffalt +6 more
doaj +1 more source
Watch the Next Step: A Comprehensive Survey of Stair-Climbing Vehicles
Robotics, 2023 Stair climbing is one of the most challenging tasks for vehicles, especially when transporting people and heavy loads. Although many solutions have been proposed and demonstrated in practice, it is necessary to further improve their climbing ability and ...
Antonio Pappalettera +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Multilateral: Jurnal Pendidikan Jasmani dan Olahraga, 2016 Effect of Arms’ Muscle Strength Exercise Through Pull Up on Improving of performance of Speed Track for the Athletes of Indonesian Rock Climbing Federation, Banjarbaru. This research uses the quasi experimental method.
Mita Erliana
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Climb and flight speeds of shorebirds embarking on an intercontinental flight; do they achieve the predicted optimal behaviour? [PDF]
Ibis, 1997 Most Arctic‐breeding waders wintering in West Africa cover the first 4000 km of their northward journey in spring by a single flight to western Europe. We examined the extent to which waders economize their flight behaviour during departure by comparing climb rates and forward flight speeds with predictions based on flight mechanic theory and the ...
Piersma, T. +3 more
openaire +1 more source