Results 61 to 70 of about 1,690,298 (261)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Influnce of VO2 max on recovery during sport climbing [PDF]

, 2010
The aim of the study was to assess the influence of aerobic fitness on the recovery speed during climbing. Methods: Fourteen climbers took part in the study. Maximal VO2 test was performed on a treadmill.
Kučerová, Adéla
core   +1 more source

Vertical locomotion improves horizontal locomotion: effects of climbing on gait and other mobility aspects in Parkinson’s disease. A secondary analysis from a randomized controlled trial

Journal of NeuroEngineering and Rehabilitation
Background In the Climb Up! Head Up! trial, we showed that sport climbing reduces bradykinesia, tremor, and rigidity in mildly to moderately affected participants with Parkinson’s disease.
Agnes Langer, Clint Hansen, Dominik Roth, Agnes Santer, Anna Flotz, Jakob Gruber, Laurenz Wizany, Sebastian Hasenauer, Rochus Pokan, Peter Dabnichki, Marco Treven, Sarah Zimmel, Michaela Schmoeger, Ulrike Willinger, Lucia Gassner, Christof Brücke, Walter Maetzler, Heidemarie Zach   +17 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Rapamycin increases climbing speed and survival.

, 2015
(A) Rapamycin treatment increases the climbing speed of 7-day-old males in both the control and FRDA fly groups, and this effect is not affected by the addition of the autophagy inhibitor 3-MA.
Sirena Soriano (348274), José Vicente Llorens (767737), Juan Botas (45480), María Dolores Moltó (767738), Pablo Calap-Quintana (767736), Ismael Al-Ramahi (85012), María José Martínez-Sebastián (767739)   +6 more
core   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Determination of climbing specific maximal oxygen uptake during climbing with increasing inclination and constant speed [PDF]

, 2012
Title of master thesis Determination of climbing specific maximal oxygen uptake during climbing with increasing inclination and constant speed. Work objectives To review the determination of climbing specific maximal oxygen uptake during climbing with ...
Kaláb, Miloš
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Study on the structural function and motion performance of pneumatic flexible tree-climbing robot.

PLoS ONE
To enhance the adaptability of tree-climbing robots to changes in tree diameter and load capacity, an "I-shaped" pneumatic flexible tree - climbing robot was designed using self-developed pneumatic flexible joints and retractable needle anchors.
Hongbo Liu, Zhipan Gou
doaj   +1 more source