Results 71 to 80 of about 172,705 (282)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Predictive Distribution of Mass and Speed Profile to Improve Aircraft Climb Prediction [PDF]

Journal of Air Transportation, 2020
Ground-based aircraft trajectory prediction is a major concern in air traffic management. Focusing on the climb phase, neural networks are trained to predict some of the unknown point-mass model parameters. These unknown parameters are the mass and the speed intent. For each unknown parameter, our model predicts a Gaussian distribution.
openaire   +4 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A VLSI implementation of the collision avoidance switch protocol for CAMB tree LANs [PDF]

, 1991
To solve a performance bottle neck in random access LANs due to packet collisions and their resolution, collision avoidance switches are introduced. These switches allow random access protocols to achieve high performance by resolving collisions among ...
Chaiyakul, Viraphol, Gajski, Daniel D., Huang, Hung, Suda, Tatsuya   +3 more
core  

Optimal climbing speed explains the evolution of extreme sexual size dimorphism in spiders [PDF]

Journal of Evolutionary Biology, 2009
AbstractSeveral hypotheses have been put forward to explain the evolution of extreme sexual size dimorphism (SSD). Among them, the gravity hypothesis (GH) explains that extreme SSD has evolved in spiders because smaller males have a mating or survival advantage by climbing faster. However, few studies have supported this hypothesis thus far.
J, Moya-Laraño, D, Vinković, C M, Allard, M W, Foellmer   +3 more
openaire   +2 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Vertical locomotion improves horizontal locomotion: effects of climbing on gait and other mobility aspects in Parkinson’s disease. A secondary analysis from a randomized controlled trial

Journal of NeuroEngineering and Rehabilitation
Background In the Climb Up! Head Up! trial, we showed that sport climbing reduces bradykinesia, tremor, and rigidity in mildly to moderately affected participants with Parkinson’s disease.
Agnes Langer, Clint Hansen, Dominik Roth, Agnes Santer, Anna Flotz, Jakob Gruber, Laurenz Wizany, Sebastian Hasenauer, Rochus Pokan, Peter Dabnichki, Marco Treven, Sarah Zimmel, Michaela Schmoeger, Ulrike Willinger, Lucia Gassner, Christof Brücke, Walter Maetzler, Heidemarie Zach   +17 more
doaj   +1 more source

Procedure for Determining Speed and Climbing Performance of Airships [PDF]

The procedure for obtaining air-speed and rate-of-climb measurements in performance tests of airships is described. Two methods of obtaining speed measurements, one by means of instruments in the airship and the other by flight over a measured ground ...
Thompson, F L
core   +1 more source

Pilots' use of a traffic alert and collision-avoidance system (TCAS 2) in simulated air carrier operations. Volume 2: Appendices [PDF]

, 1989
Pilots' use of and responses to a traffic alert and collision-avoidance system (TCAS 2) in simulated air carrier line operations are discribed in Volume 1.
Billings, Charles E., Chappell, Sheryl L., Kozon, Thomas E., Olsen, M. Christine, Scott, Barry C., Tuttell, Robert J.   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source