A Quadratic Bifactor Hierarchical Model for Jointly Modelling the Nonlinear Relationship Between Response Accuracy and Response Time in Cognitive Testing. [PDF]
J IntellGuo X, He X, Bai X, Yan J.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Experimental Study on Slicing Sapphire Crystal with Ultrasonic-Assisted Diamond Wire Saw. [PDF]
Micromachines (Basel)Ismael F, Sun P, Liu Y, Li H, Gao Y.
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
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A two-stage unified Bayesian framework for adolescent physical fitness surveillance in Sichuan, China: Latent factor measurement followed by spatiotemporal modeling. [PDF]
PLoS OneWei H, Li H, Pu M, He Z, Wang Y.
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
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Optimization of Nanosecond Laser Polishing Process for TC4-B<sub>4</sub>C Composite Material and Study on Surface Quality. [PDF]
Materials (Basel)Zhang J, Yang Y, Zhu L, Xu W, Liu Z.
europepmc +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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Multi-Objective Optimization of FDM Dimensional Accuracy for PLA/TPU Blends Based on Entropy Weight-TOPSIS and Orthogonal Array Design. [PDF]
Polymers (Basel)Li P, Wei T, Yang L, Zhao J, Wang S.
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source