Results 81 to 90 of about 345,568 (255)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins. [PDF]
Elife, 2023 Kim S, Lee D, Wijesinghe WCB, Min D.
europepmc +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Geometric Speed Limit of Accessible Many-Body State Preparation
Physical Review X, 2019 We analyze state preparation within a restricted space of local control parameters between adiabatically connected states of control Hamiltonians. We formulate a conjecture that the time integral of energy fluctuations over the protocol duration is ...
Marin Bukov +2 more
doaj +1 more source
Unifying speed limit, thermodynamic uncertainty relation and Heisenberg principle via bulk-boundary correspondence. [PDF]
Nat Commun, 2023 Hasegawa Y.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Impact of speed limit method on motorway safety
Građevinar, 2016 Results obtained during the study of various speed limit methods, including uniform, differential, and lane-based methods, are presented in this paper. The results show that the LBSL strategy is by 20 % better than other methods when safety is considered,
Mostafa Adresi +3 more
doaj +1 more source
Multi-Lane Differential Variable Speed Limit Control via Deep Neural Networks Optimized by an Adaptive Evolutionary Strategy. [PDF]
Sensors (Basel), 2023 Feng J, Shi T, Wu Y, Xie X, He H, Tan H.
europepmc +1 more source
Reconciling Speed Limits with Design Speeds
, 2004 In recent years, context-sensitive highway design has been promoted to ensure that designers consider the environmental, scenic, aesthetic, historic, community, and preservation aspects of the road. Context-sensitive design may lead to situations where the current design standards cannot be met because of restricting local conditions.
Figueroa-Medina, Alberto Miguel +1 more
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source