Results 61 to 70 of about 257,500 (259)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Rationale for the recommendation to improve the carrying capacity access roads pc «Pavlogradugol»
Nauka ta progres transportu, 2012 The results of studies on the дdevelopment of recommendations to improve the capacity and carrying capacity of the access road PC «Pavlogradugol».
V.V.Kovalev +4 more
doaj
Wasserstein speed limits for Langevin systems
Physical Review ResearchPhysical systems transition between states with finite speed that is limited by energetic costs. In this work, we derive bounds on transition times for general Langevin systems that admit a decomposition into reversible and irreversible dynamics, in ...
Ralph Sabbagh +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Certified Randomness From Quantum Speed Limits
PRX QuantumQuantum speed limits are usually regarded as fundamental restrictions, constraining the amount of computation that can be achieved within some given time and energy.
Caroline L. Jones +3 more
doaj +1 more source
Noise limited computational speed [PDF]
Applied Physics Letters, 2007 In modern transistor based logic gates, the impact of noise on computation has become increasingly relevant since the voltage scaling strategy aimed at decreasing the dissipated power, has increased the probability of error due to the reduced switching threshold voltages.
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Speed Limits in the Safe System Context
Journal of Road Safety, 2010 This paper proposes a set of new principles for setting speed limits based on harm minimisation, the cornerstone of the Safe System approach. The Safe System approach seeks to develop and manage the road transport system so that death and serious injury ...
C Jurewicz
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source