Results 41 to 50 of about 4,184,316 (250)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization design for aerodynamic elements of high speed trains

, 2014
The complex wake flow of high speed trains severely influences the running safety and amenity of the trailing car. In this paper, based on the streamlined shape of CRH380A high speed train, taking the aerodynamic lift force of the trailing car and the ...
孙振旭, 杨国伟, Sun, ZX (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China., 姚拴宝, 郭迪龙, 陈大伟   +5 more
core   +1 more source

Comparison of the convergence speed of different optimization methods.

, 2022
Comparison of the convergence speed of different optimization methods.
Min Zhao (66793), Qin Wang (109812), Zhihan Lv (385901), Yangda Gong (12015173)   +3 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Analysis of Control Behavior in Eco-Driving Speed Optimization Using Pontryagin’s Minimum Principle

IEEE Access
The energy efficiency of autonomous vehicles can be improved by selecting an optimized speed profile. Energy savings can be maximized by performing control optimization with knowledge of the powertrain characteristics and future driving conditions ...
Shaowen Lyu, Liyue Yang, Daliang Shen, Jihun Han, Dominik Karbowski, Namwook Kim   +5 more
doaj   +1 more source

Shape Optimization of High-Speed Train with the Speed of 500kph

, 2012
With the train speed becoming faster and faster, the aerodynamic drag turns to be one of the essential factor that restricts the train speed ascent.
Gao TY, Wang XP, Yang GW(杨国伟), Cui K(崔凯), Hu SC, Guowei Yang, X. P. Wang, K. Cui, T. Y. Gao, S. C. Hu   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Three-dimensional aerodynamic optimization design of high-speed train nose based on GA-GRNN

, 2012
With the speed upgrade of the high-speed train, the aerodynamic drag becomes one of the key factors to restrain the train speed and energy saving.
Yao SB(姚拴宝), Guo DL(郭迪龙), Yang GW(杨国伟)   +2 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source