Results 101 to 110 of about 175,082 (350)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
The Effect of Display Polarity on Reading Speed and Reading Error Among Young Adults
Journal of Health Science and Medical Research (JHSMR)Objective: The widespread adoption of digital devices has surged, particularly since the coronavirus disease 2019 (COVID-19) pandemic. Nearly everyone now owns devices like laptops, tablets, or smartphones, offering options for light mode (positive ...
Nurulain Muhamad, Nurliyana Mokhtar
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The relation between executive functioning, reaction time, naming speed, and single word reading in children with typical development and language impairments [PDF]
, 2016 David Messer, Lucy A. Henry, Gilly Nash
openalex +1 more source
Analysis of The Influence of Reading Speed and Reading Reference on Reading Comprehension Skills With Reading Strategy as Mediation Variables for Students at State University of Padang [PDF]
, 2023 Amril Amir
openalex +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Optimal line length for reading schoolbook on screen
, 2013 Although experimental studies have shown a strong impact of text layout on the legibility of e- text, many digital texts appearing in eBook or the internet use different designs, so that there is no straightforward answer in the literature over which one
Abubaker, Azza, Lu, Joan
core
Visual Aspects of Reading Performance in Myalgic Encephalomyelitis (ME)
Frontiers in Psychology, 2018 People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) report vision-related reading difficulty, although this has not been demonstrated objectively.
Rachel L. Wilson +3 more
doaj +1 more source