Results 131 to 140 of about 645,874 (305)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Experiment and simulation on air layer drag reduction of high-speed underwater axisymmetric projectile

, 2015
Injection of air could lead to creation of a bubbly mixture or air layer near the surface that can significantly adjust the flow within the turbulent boundary layer. In this paper, stress wave propagation techniques and Split Hopkinson Pressure Bar (SHPB)
Wei YP(魏延鹏), Wu XC(吴小翠), Du TZ(杜特专), Yu XX(于娴娴), Fang X(方欣), Wang YW(王一伟), Huang CG(黄晨光), Wang, YW (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China.   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

20mph speed reduction initiative

, 2001
Summary of report '20mph speed reduction initiative'Available from British Library Document Supply Centre-DSC:3579.0194(no 104) / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Burns, A., Scottish Executive, Edinburgh (United Kingdom). Central Research Unit, Macdonald, N., Johnstone, N.   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Motor speed reduction methods

, 2012
A.C. motors usually come in standard output speeds of 3600, 1800, 1200 or 900 revolutions per minute (rpms), but the machines they power generally require different input speeds. In order to get to the required input speed for a particular piece of
Fairchild, Fred J.
core  

Transient Vibration Loads Characteristics Analysis of Variable Speed Rotor

Applied Sciences
To investigate the rotor vibration loads during the variable speed transient process, a transient rotor aeroelastic method based on the medium beam deformation theory and Hamilton’s principle is developed to simulate the rotor transient dynamic loads in ...
Zhihao Yu, Chunhua Li, Jian Huang, Yi Cheng   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Seabed Protection Systems to prevent Scour from High-Speed Ships [PDF]

, 2010
This document reviews the scour protection systems required around port structures where these are to be used for the berthing of vessels powered by water jet systems.
Evans, G.
core