Results 111 to 120 of about 645,874 (305)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Speed Management and Speed Reduction in Portland, OR

, 2022
In 2015, the Portland City Council unanimously passed a resolution committing Portland to Vision Zero, the goal to eliminate traffic deaths and serious injuries. An underpinning of Vision Zero is that streets are managed for safe speeds.
Veka, Clay, Anderson, Jason C.
core  

Efficiency of noise reduction by a road speed bump

Archives of Acoustics, 2014
The vehicle noise from a road with a bump consists of the deceleration noise, bump noise, and acceleration noise. The bump is modeled by the Dirac delta function.
Rufin MAKAREWICZ, Piotr KOKOWSKI
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Design Tradeoffs Between Constant Power Speed Range,Uncontrolled Generator Operation and Rated Current of IPM MotorDrives [PDF]

, 2010
A closed-form approximate formulation is proposed to establish a relationship between the uncontrolled generator operation of IPM motors at high speed and the constant power speed range and drive current capabilities.
P. Guglielmi, Paolo Guglielmi, Pellegrino, Gian-Mario Luigi, Guglielmi, Paolo, A. Vagati, Vagati, Alfredo, Gianmario Pellegrino, Alfredo Vagati, PELLEGRINO, GIAN - MARIO LUIGI, G. Pellegrino   +9 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Effect of Speed Linear Decrease on Internal Flow Characteristics and Pressure Pulsations of Variable-Speed Pump Turbine in Turbine Mode

Journal of Marine Science and Engineering
Pumped storage units often deviate from the optimal operating conditions in the process of regulating new energy fluctuations. To effectively improve the performance of the units, the variable speed of the units is one of the more feasible means at ...
Guangtai Shi, Binyan Li, Yexiang Xiao, Manqi Tang, Xi Yang   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Advisory Intelligent Speed Adaptation for government fleets

, 2011
This project sought to determine the likely crash savings if state government fleets in Australia were fitted with advisory Intelligent Speed Adaptation (ISA).
Anderson, R., Woolley, J., Doecke, S.D.
core