Results 81 to 90 of about 3,958,960 (312)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Financial Inclusion Trilemma

This page contains the data necessary to replicate the results of "The Financial Inclusion Trilemma" by Adam J. Levitin, published in the Yale Journal on Regulation (2024)
Journal on Regulation, Yale
core   +1 more source

Plant Inversion-Based Speed Control of a PMDC Motor

Eng
Permanent Magnet Direct Current (PMDC) motors are widely used in applications requiring precise speed control due to their efficiency and high torque-to-inertia ratio. This work proposes a feedforward speed control strategy for PMDC motors based on model
Joel Artemio Morales-Viscaya, Leonardo Corral-Trigueros, Merlín Octavio Maravilla, Marco Antonio Castro-Liera, Martin Moreno, Alberto Traslosheros-Michel   +5 more
doaj   +1 more source

Financial Regulation and the Speed of Financial Risks

Œconomia, 2017
This paper argues that the speed of financial risks, rather than the speed of regulators, is the key cause of financial crises. Our argument contradicts a common claim in the literature that financial crises arise because regulators cannot keep up with ...
Ralph Chami, Thomas Cosimano, Connel Fullenkamp, Celine Rochon   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Physics-Guided Surrogate-Assisted Reinforcement Learning for Multi-Objective Coordinated Speed Control of a Shearer Under Complex Coal–Rock Conditions

Machines
Advanced manufacturing and cutting machinery often operate under variable material properties and uncertain load conditions, making real-time process optimization difficult when high-fidelity simulations and physical experiments are costly.
Lijuan Zhao, Zhanpeng Zhang, Tiangu Wu, Yadong Wang, Shutian Gong   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Discretionary Investing by ‘Passive’ S&P 500 Funds

This page contains the code and data necessary to replicate the results of "Discretionary Investing by ‘Passive’ S&P 500 Funds" by Peter Molk & Adriana Z. Robertson, published in the Yale Journal on Regulation (2024)
Journal on Regulation, Yale
core   +1 more source

On the stability of high-speed milling with spindle speed variation [PDF]

, 2010
Spindle speed variation is a well-known technique to suppress regenerative machine tool vibrations, but it is usually considered to be effective only for low spindle speeds.
Arnaud, Lionel, Insperger, Tamás, Peigné, Grégoire, Seguy, Sébastien, Dessein, Gilles   +4 more
core   +1 more source

Power-speed coupling response characteristics of variable speed pumped storage unit under pumping mode

International Journal of Electrical Power & Energy Systems
Variable speed pumped storage unit (VSPSU) has the advantage of adjustable power under pumping mode, which can better meet the regulation demand of power grid.
Rui Cao, Wencheng Guo, Chao Wang
doaj   +1 more source