Results 71 to 80 of about 1,541,068 (336)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Spent Fuel and Fuel Pool Component Integrity. Annual Report, FY 1980

, 1981
During program FY 1980 staff members of the Spent Fuel and Fuel Pool Component Integrity Program at Pacific Northwest Laboratory (PNL) completed the following major tasks: represented DOE on the international Behavior of Fuel Assemblies in Storage ...
D.C. Langstaff, W.J. Bailey, Bradley, E. R., Bailey, W. J., Bruemmer, S. M., E.R. Bradley, Johnson, A. B., (Jr.), A.B. Jr. Johnson, Langstaff, D. C., S.M. Bruemmer   +9 more
core   +1 more source

Dose rate profile inside the spent fuel storage pool in case of full capacity storage [PDF]

, 2020
This study aims to evaluate the radiation dose rate distribution inside temporary spent fuel open-pool storage. The storage pool is connected to the main pool via transfer channel to facilitate transporting the spent fuel under water that avoiding ...
Abdelhady, Amr
core   +1 more source

Minimizing the Standard Deviation of the Thermal Load in the Spent Nuclear Fuel Cask Loading Problem

Energies, 2020
The paper assumes that, at the end of the operational period of a Spanish nuclear power plant, an Independent Spent Fuel Storage Installation will be used for long-term storage. Spent fuel assemblies are selected and transferred to casks for dry storage,
Joaquín Bautista-Valhondo, Lluís Batet, Manuel Mateo   +2 more
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Natural Convection Heat Transfer of the Horizontal Rod-Bundle in a Semi-closed Rectangular Cavity

Frontiers in Energy Research, 2020
During the refueling of PWR, the spent fuel assemblies are transferred from the reactor building to the fuel building through an underwater tube. The heat transfer characteristics of the spent fuel assembly in the top-corner area of the carrier with poor
Xi-dao Mao, Xi-dao Mao, Hong Xia
doaj   +1 more source

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Development of the Noncontact Temperature Sensor Using the Infrared Optical Fiber Coated with Antifog Solution

Science and Technology of Nuclear Installations, 2015
This study developed a noncontact fiber-optic temperature sensor that can be installed in a spent nuclear fuel pool. This fiber-optic temperature sensor was fabricated using an infrared optical fiber to transmit the infrared light emitted from water at a
Rinah Kim, Chan Hee Park, Arim Lee, Joo Hyun Moon   +3 more
doaj   +1 more source

Sensitivity studies in spent fuel pool criticality safety analysis for APR-1400 nuclear power plants

Nuclear Engineering and Technology, 2018
A criticality safety analysis was performed for the APR-1400 spent fuel pool region-II to ensure the safe storage of spent fuel, with credit taken for depletion and in-rack neutron absorbers (Metamic panels).
Abdulrahman S. Al Awad, Abdalla Habashy, Walid A. Metwally   +2 more
doaj   +1 more source