Results 111 to 120 of about 489,854 (362)

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Relative safety of various spermatogenic stem cell purification methods for application in spermatogenic stem cell transplantation

Stem Cell Research & Therapy, 2019
Background Spermatogonial stem cell (SSC) transplantation technology as a promising option for male fertility preservation has received increasing attention, along with efficient SSC purification technology as a necessary technical support; however, the ...
Jia Tian, Ke Ma, Cheng-bin Pei, Shao-hua Zhang, Xue Li, Yue Zhou, Bei Yan, Hong-yan Wang, Liang-hong Ma   +8 more
doaj   +1 more source

Etiologies of sperm oxidative stress

International Journal of Reproductive BioMedicine, 2016
Sperm is particularly susceptible to reactive oxygen species (ROS) during critical phases of spermiogenesis. However, the level of seminal ROS is restricted by seminal antioxidants which have beneficial effects on sperm parameters and developmental ...
P. Sabeti, S. Pourmasumi, T. Rahiminia, F. Akyash, A. Talebi   +4 more
semanticscholar   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Decline in human sperm counts during the past 50 years? [PDF]

, 2005
There is widespread concern that environmental pollutants acting as xenoestrogens may affect human fertility adversely. Whether this has already made an impact on human fertility worldwide remains debatable at the present stage.
Souza, Urban JAD, Pinto, Maxim, Jayachandra, Srinivasa   +2 more
core  

The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs

, 2004
BACKGROUND: The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm.
Xiao P Zhai, Homa, ST, Christopikou Dimitra, Christopikou, D, Homa, Sheryl T., Zhai, Xiao-Ping, Tempest, Helen G., Dalakiouridou, Maria, Griffin Darren K, David Wright, Wright, David B., Darren K Griffin, Sheryl T Homa, Wright, D, Maria Dalakiouridou, Griffin, DK, Dimitra Christopikou, Wright David, Homa Sheryl T, Dalakiouridou Maria, Tempest Helen G, Tempest, HG, Helen G Tempest, Dalakiouridou, M, Zhai Xiao P, Zhai, XP, Christopikou, Dimitra, Griffin, Darren K.   +27 more
core   +1 more source

Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males [PDF]

, 2011
Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility.
Tresch, A., N. El Hajj, M. Schorsch, Haaf, T., Hahn, T., U. Zechner, E. Schneider, T. Hahn, T. Haaf, El Hajj, N., Gromoll, J., Schorsch, M., A. Tresch, Schneider, E., Zechner, Ulrich, J. Gromoll   +15 more
core   +1 more source

Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers

Advanced Science, EarlyView.
Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang, Chong Wang, Mengqi Han, Yi Yang, Teng Ma, Luoran Shang   +5 more
wiley   +1 more source

Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone

Science, 2016
Progesterone signaling in sperm Cumulus cells surrounding the ovulated egg release the female hormone progesterone, which is necessary for sperm activation in mammals. Miller et al.
Melissa R. Miller, N. Mannowetz, A. Iavarone, Rojin Safavi, Elena O. Gracheva, James F. Smith, Rose Z. Hill, D. Bautista, Yuriy Kirichok, P. Lishko   +9 more
semanticscholar   +1 more source

Computational Modelling of Sperm Behaviour in a 3D Virtual Oviduct [PDF]

, 2011
The processes by which individual sperm cells navigate the length and complexity of the female reproductive tract and then reach and fertilise the oocyte are fascinating. Numerous complex processes potentially influence the movement of spermatozoa within
Burkitt, Mark
core