Results 81 to 90 of about 1,670,435 (349)

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Clinical management of infertile men with nonobstructive azoospermia

Asian Journal of Andrology, 2015
The clinical management of men with nonobstructive azoospermia (NOA) seeking fertility has been a challenge for andrologists, urologists, and reproductive medicine specialists alike.
Sandro C Esteves
doaj   +1 more source

Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs [PDF]

, 2015
© The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 26 (2015): 3628-3640, doi:10.1091/mbc.E15-04-0233.Mitotic spindles ...
Field, Christine M., Groen, Aaron C., Mitchison, Timothy J., Nguyen, Phuong A.   +3 more
core   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Artificial intelligence model for the assessment of unstained live sperm morphology

Reproduction and Fertility
Traditional sperm morphology assessment requires staining and high magnification (100×), rendering sperm unsuitable for further use. We aimed to determine whether an in-house artificial intelligence (AI) model could reliably assess normal sperm ...
Jermphiphut Jaruenpunyasak, Prawai Maneelert, Marwan Nawae, Chainarong Choksuchat   +3 more
doaj   +1 more source

Integrating Quality Management and Male Reproductive Health in Assisted Reproduction [PDF]

International Brazilian Journal of Urology
Quality management is essential to ensure consistent, safe, and effective outcomes in assisted reproductive technology (ART) centers. However, traditional quality assessments often overlook male infertility, which contributes to nearly half of all ...
Fabiola C. Bento, Rita C. S. Figueira, Sandro C. Esteves   +2 more
doaj   +1 more source

Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver Nanoparticles Released from Medical Devices [PDF]

, 2017
Silver nanoparticles (AgNP) are incorporated into medical devices for their anti-microbial characteristics. The potential exposure and toxicity of AgNPs is unknown due to varying physicochemical particle properties and lack of toxicological data. The aim
Brown, Ronald P., Goering, Peter L., Malghan, Subhas G., Merrill, Stephen, Nagy, Amber M., Pradeep, Prachi, Savery, Laura C., Vinas, Rene   +7 more
core   +1 more source

Ultrafast Dense Immobilization of Noble Metal Nanoparticles on Customizable Multifunctional Polymer Microspheres for Heterogeneous Catalysis and Multiplexed Biodetection

Advanced Science, EarlyView.
This work proposes a facile co‐assembly strategy to achieve highly uniform and dense immobilization of diverse noble metal nanoparticles onto metastable multifunctional (e.g., magnetic or fluorescent) polymer microspheres, enabling fabrication of complex hierarchical superstructures.
Jie Zhao, Xinyi Liu, Dan Li, Xuefei Jing, Weijie Wu, Liangrui He, Yizhang Tang, Zhen Liu, Yulin Zeng, Haitian Sha, Huibin Qiu, Xujiang Yu, Wanwan Li   +12 more
wiley   +1 more source

Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

Andrologia, 2020
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in various clinical infertility scenarios and the advances on sperm DNA fragmentation tests. The collected evidence was used to formulate 41 recommendations.
S. Esteves, A. Zini, R. Coward, D. Evenson, J. Gosálvez, S. Lewis, R. Sharma, P. Humaidan   +7 more
semanticscholar   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source