Results 71 to 80 of about 285,253 (302)

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Protective Effect of L-Carnitine on the Sperm Parameters of Adult Mice Treated with Ciprofloxacin

Journal of Ardabil University of Medical Sciences, 2018
Background & objectives: The present study examined the gonadotoxic effects of ciprofloxacin antibiotics and protective effects of L-carnitine. Methods: In this study, 20 NMRI mice were divided into four groups: control, ciprofloxacin, L-carnitine, L ...
Mina Kiani, Paria Parto
doaj  

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Relationship between sperm progressive motility and DNA integrity in fertile and infertile men

Middle East Fertility Society Journal, 2018
Background: Progressive sperm motility was found to be predictive for in vitro and in vivo fertilization. There has been an increase in the literature of studies investigating whether DNA fragmentation could be associated with other semen parameters ...
Salah Elbashir, Yasmin Magdi, Ayman Rashed, Mohamed Ahmed Ibrahim, Yehia Edris, Ahmed Mostafa Abdelaziz   +5 more
doaj   +1 more source

Low Sperm Motility Is Determined by Abnormal Protein Modification during Epididymal Maturation

The World Journal of Men's Health, 2022
Purpose:Purpose: During epididymal sperm maturation, spermatozoa acquire progressive motility through dynamic protein modifica-tions. However, the relationship between sequential protein modifications during epididymal sperm maturation and sperm motility
Yoo-Jin Park, Byeong-Mu Lee, Won-Ki Pang, Do-Yeal Ryu, Md Saidur Rahman, Myung-Geol Pang   +5 more
doaj   +1 more source

Habitat‐Specific Design Strategies for Untethered Soft Robots

Advanced Science, EarlyView.
Habitat shapes the design of untethered soft robots. Across land, water, air, and living tissues, environmental constraints govern viable combinations of compliant structures, actuation mechanisms, and energy delivery. This review connects these constraints with robotic performance and identifies design principles for advancing adaptable, durable, and ...
Siyang Li, Zhikun Miao, Tuck‐Whye Wong, Tiefeng Li   +3 more
wiley   +1 more source

Molecular approaches based on investigating the therapeutic benefits of Moringa oleifera: Insights into biochemical and spermatological and metabolites studies

Aspects of Molecular Medicine
This study aimed to investigate the potential of Moringa oleifera extract, an herbal treatment known to support male reproductive function, in improving sperm motility. Adult male guinea pigs were divided into four groups (n = 5 per group).
Sudha Sankar, Subramaniam Umavathi, Ekambaram Gayathiri, Palanisamy Prakash   +3 more
doaj   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Sperm motility and viability percentages of thirty sperm samples before and after cryopreservation and Percoll separation.

, 2018
Sperm motility and viability percentages of thirty sperm samples before and after cryopreservation and Percoll separation.
Marek Rodina (5638718), Ievgen Lebeda (5638712), Mariola A. Dietrich (4993373), Pavlo Fedorov (5638715), Borys Dzyuba (5638721), Yevhen Horokhovatskyi (5638709)   +5 more
core   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source