Results 111 to 120 of about 20,361 (253)

Coordinating Fertility Preservation in Children and Young Adults at Risk of Treatment‐Induced Infertility: A Commentary

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
Ursula Blyth, Pedro Melo, Rod T. Mitchell, Suzannah A. Williams, Ephia Yasmin, Phillipa Sangster, Kokila Lakhoo, Sheila Lane, Richard A. Anderson, Christian M. Becker   +9 more
wiley   +1 more source

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Hyperactivation and Tyrosine Phosphorylation of Cryopreserved Stallion Spermatozoa in Relation to Conventional In Vitro Fertilization Blastocyst Production

Andrology, EarlyView.
ABSTRACT Background Challenges in establishing clinical conventional in vitro fertilization (IVF) in horses include variation in sperm and oocyte quality, which can be affected by mare age. Extended preincubation of stallion spermatozoa has resulted in successful IVF.
Raul A. Gonzalez‐Castro, Carolina C. Porflidt, Alexandra L. Ash, Jacobo S. Rodriguez, Perla D. Fleury, Edward L. Squires, Elaine M. Carnevale   +6 more
wiley   +1 more source

Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men

Frontiers in Endocrinology
IntroductionAzoospermia, characterized by an absence of sperm in the ejaculate, represents the most severe form of male infertility. While surgical sperm retrieval in obstructive azoospermia (OA) is successful in the majority of cases, patients with non ...
Daniela Fietz, Raouda Sgaier, Raouda Sgaier, Raouda Sgaier, Liza O’Donnell, Liza O’Donnell, Peter G. Stanton, Peter G. Stanton, Laura F. Dagley, Laura F. Dagley, Andrew I. Webb, Andrew I. Webb, Hans-Christian Schuppe, Thorsten Diemer, Adrian Pilatz   +14 more
doaj   +1 more source

Shear wave elastography for predicting the likelihood of sperm retrieval in microscopic testicular sperm extraction [PDF]

Background: The gold standard procedure for retrieving mature sperm cells from the foci of spermatogenesis in the testicles of patients with nonobstructive azoospermia (NOA) is called microscopic testicular sperm extraction (micro-TESE).
İsmail Yağmur, Halil Çiftçi, Adem Tunçekin, Mehmet Demir, Bülent Katı, Eyyup Sabri Pelit   +5 more
core   +1 more source

Limited Clinical Impact of Androgen Receptor Repeat Length (CAG and GGC) in Klinefelter Syndrome: A Multivariable Analysis

Andrology, EarlyView.
ABSTRACT Background Klinefelter syndrome (KS) is characterized by marked phenotypic heterogeneity that might be influenced by genetic modifiers, including androgen receptor (AR) repeat length (CAGn and GGCn). The clinical relevance of these repeat lengths in patients with KS before testosterone replacement therapy (TRT) remains unclear.
Andrea Graziani, Alberto Scala, Maria Santa Rocca, Cinzia Vinanzi, Giuseppe Grande, Andrea Di Nisio, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +8 more
wiley   +1 more source

Testis sperm extraction

, 2015
The last 20 years have produced developments in the treatment for patients with non-obstructive azoospermia (NOA) who were once considered to be infertile.
Dabaja, Ali A., Janosek-Albright, Kirsten J.C., Schlegel, Peter N.   +2 more
core   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Policy on Posthumous Sperm Retrieval: Survey of 75 Major Academic Medical Centers

, 2018
To evaluate the presence and content of policies on posthumous sperm retrieval at 75 major academic medical centers in the U.S. We surveyed the top 75 major academic medical centers ranked for research in 2016 by U.S.
Nancy L. Brackett, Nicholas J. Waler, Charles M. Lynne, Lynne, Charles M, Waler, Nicholas J, Raul I. Clavijo, Clavijo, Raul I, Ramasamy, Ranjith, Ranjith Ramasamy, Brackett, Nancy L   +9 more
core   +1 more source