Results 141 to 150 of about 20,361 (253)

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1773-1782, August 2026.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman, Carli M. Tops, Jelmer Legebeke, Ting Yang, Marcos Díaz Gay, Diantha Terlouw, Lisa E. E. L. O. Lashley, Stefan Aretz, Anna K. Sommer, Mariona Terradas, Laura Valle, Richarda M. de Voer, Ludmil B. Alexandrov, Hans Morreau, Tom van Wezel, Maartje Nielsen   +15 more
wiley   +1 more source

In Vitro Fertilization is Essential Healthcare for Patients With Rheumatic Disease

ACR Open Rheumatology, Volume 8, Issue 7, July 2026.
Infertility presents a profound physical, emotional, and financial burden, particularly for rheumatology patients who often face substantial barriers to family building. The 2024 Alabama Supreme Court ruling in LePage v. Center for Reproductive Medicine equating embryo destruction with wrongful death introduced new legal uncertainties, sparking ...
Amanda Moyer, Catherine A. Sims, Rosalind Ramsey‐Goldman, Solmaz Chamanara, Cuoghi Edens   +4 more
wiley   +1 more source

Intratesticular Testosterone and Its Precursors among Azoospermic Men: A Pilot Study

The World Journal of Men's Health
Purpose: The study aimed to comprehensively analyze testosterone and precursor concentrations in the testicular interstitial fluid (TIF) of men with azoospermia, exploring their significance in the testicular microenvironment and their correlation with
I-Shen Huang, Li-Hua Li, Wei-Jen Chen, Chi-Chang Juan, William J. Huang   +4 more
doaj   +1 more source

Cryopreservation of testicular and epididymal sperm: techniques and clinical outcomes of assisted conception

Clinics, 2013
The introduction of the technique of intracytoplasmic sperm injection to achieve fertilization, especially using surgically retrieved testicular or epididymal sperm from men with obstructive or non-obstructive azoospermia, has revolutionized the field of
Bhushan K. Gangrade
doaj  

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, Volume 13, Issue 37, 3 July 2026.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

High Early Embryo Mortality and Low Hatching Success Observed in Aldabra Giant Tortoise Populations

Ecology and Evolution, Volume 16, Issue 7, July 2026.
This preliminary study provides the first population‐level assessment of fertilisation and hatching success in the Aldabra giant tortoise across natural and translocated populations in Seychelles, revealing low and highly variable hatching success—particularly in translocated populations.
Alessia Marialydia Lavigne, Richard Baxter, Eric Blais, Mark Brown, Robert Bullock, Christina Marques, Angelin Bernardis Sanders, Nirmal Jivan Shah, Chris Tagg, Elisabeth Wareing, James Wareing, Nicola Hemmings   +11 more
wiley   +1 more source

Semen Quality and DNA Fragmentation After Limited Testicular Sperm Extraction in Non‐Azoospermic Men With ART Failure: A Retrospective Matched Cohort Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Testicular sperm extraction (TESE) is sometimes used in non‐azoospermic men with persistent infertility, particularly in cases of high sperm DNA fragmentation index (DFI) or repeated intracytoplasmic sperm injection (ICSI) failure.
Naser Amirjannati, Hamed Akhavizadegan, Arash Mohazzab, Negin Amirjannati, Manizheh Fathalian, Ghazaleh Eslamian   +5 more
wiley   +1 more source

Gonadotropin Stimulation Before Sperm Retrieval in Non-Obstructive Azoospermia: Myth, Magic, or Medicine? [PDF]

Int Braz J Urol
Viana MC, Achermann APP, Andrade DL, Miyaoka R, Esteves SC.   +4 more
europepmc   +1 more source

Hepatoprotective Potential of Eugenol Against Pesticide Glyphosate‐Induced Liver Injury via Nrf2/HO‐1 Signaling and Modulation of Apoptosis and Inflammation in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 7, July 2026.
Glyphosate was administered orally to rats at the specified doses. At the end of the study, liver tissues were collected for analysis. These tissues were used to perform Western blot, RT‐PCR, liver enzyme assays, and lipid peroxidation measurements.
Esra Aktas Senocak, Omercan Alat, Ismail Bolat, Burak Batuhan Lacin, Samet Tekin, Aslıhan Atasever, Merve Bolat, Mesut Bunyami Halici   +7 more
wiley   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source