Results 51 to 60 of about 5,887,583 (287)

Post-Meiotic Intra-Testicular Sperm Senescence in a Wild Vertebrate [PDF]

, 2012
There is growing interest in sperm senescence, both in its underlying mechanisms and evolutionary consequences, because it can impact the evolution of numerous life history traits. Previous studies have documented various types of sperm senescence, but
Richard H. Wagner, Penn, Dustin J., Richard H Wagner, Hoi Herbert, Wagner, Richard H., Hettyey Attila, Hoi, Herbert, Attila Hettyey, Dustin J. Penn, Balázs Vági, Herbert Hoi, Vági Balázs, Wagner Richard H., Penn Dustin J., Hettyey, Attila, Vági, Balázs, Dustin J Penn   +16 more
core   +2 more sources

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

Clinical Outcomes and Live Birth Rate Resulted From Microdissection Testicular Sperm Extraction With ICSI-IVF in Non-Obstructive Azoospermia: A Single-Center Cohort Study

Frontiers in Endocrinology, 2022
BackgroundMost of data available in the literature reported the sperm retrieval rate and limited intracytoplasmic sperm injection (ICSI) results of microdissection testicular sperm extraction (micro-TESE) in non-obstructive azoospermia (NOA) patients ...
Yu Lan, Haiyan Zheng, Xin Fu, Tianwen Peng, Chen Liao, Jianan Liu, Min Liu, Geng An   +7 more
doaj   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Outcomes of microdissection testicular sperm extraction in azoospermic men following chemotherapy: A cross-sectional study

International Journal of Reproductive BioMedicine
Background: The use of chemotherapy agents can increase the likelihood of azoospermia in men. Today, the application of micro-dissection testicular sperm extraction (micro-TESE) and subsequent intracytoplasmic sperm injection (ICSI) is recommended for ...
Mehdi Babaei, Mohammad Ali Sadighi Gilani, Mahdi Ramezani-Binabaj, Hamid Arasteh, Seyed Reza Yahyazadeh   +4 more
doaj   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

Building families—Implementing balanced sexual and reproductive health

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning and family building.
Peter Y. Liu, Edgar Mocanu, Linda Giudice, Marcos Horton, Meletios P. Nigdelis, Antti Perheentupa, Andrea Sansone, Giovanni Corona, Luca Gianaroli, Dimitrios G. Goulis   +9 more
wiley   +2 more sources

Microsurgical Testicular Sperm Extraction Results in Nonobstructive Azospermic Disease and Evaluation of the Factors Affecting These Results

Acta Medica Alanya, 2017
Aim: To investigate the hormonal properties and results of 71 patients, who were diagnosed with nonobstructive azoospermia (NOA) and performed micro-TESE (microsurgical testicular sperm extraction) at  our clinic, and the relationship of these results ...
Murat Uçar, Taylan Oksay, Alper Özorak, Sedat Soyupek, Abdullah Armağan, Alim Koşar   +5 more
doaj   +1 more source

Post-mortem sperm retrieval in Australasia

, 2012
Post-mortem Sperm Retrieval (PMSR) is seldom requested in Australasia. The retrieval of sperm is permitted only by prior written consent or by order of the court.
Yazdani, Anusch, Kroon, Frederick, Wong, Brittany, Kroon, Benjamin, Holt, Saul   +4 more
core   +1 more source