Results 191 to 200 of about 86,647 (289)

Impact of the defined Oligo-MM¹² microbiota on intestinal colonisation and dissemination of Listeria monocytogenes. [PDF]

Sci Rep
Cazzaniga M, Bra KK, Herzog MKM, Hardt WD, Claesson MJ, Mathur H, Gahan CGM.   +6 more
europepmc   +1 more source

RGS16 Aggravates Hepatic Ischemia‐Reperfusion Injury via Hepatocyte‐Intrinsic Apoptosis/Inflammation & Neutrophil Recruitment/NETosis

Advanced Science, EarlyView.
RGS16 competitively interferes with the YTHDF3–PAN3 complex to prevent CXCL1 mRNA decay during hepatic ischemia‐reperfusion injury. Stabilized CXCL1 strengthens hepatocyte injury, neutrophil recruitment, and NET‐associated inflammation, uncovering how stress‐induced RGS16 converts post‐transcriptional regulation into immune‐mediated liver damage ...
Xinglong Li, Zhanzhi Meng, Hongjun Yu, Yongliang Hua, Zihao Li, Bing Yin, Baolin Qian, Zhongyu Li, Yongzhi Zhou, Zhigang Feng, Shounan Lu, Shanjia Ke, Miaoyu Bai, Yao Fu, Wei Tang, Natalia V. Belosludtseva, Yong Ma   +16 more
wiley   +1 more source

Loss of microbial signals reprograms endocrine microenvironments and consistently reduces RESISTIN expression in the adrenal and thyroid cells of germ-free pigs. [PDF]

Genes Dis
Tian J, Wang T, Zhou T, Pan Y, Shang H, Li S, Yang S, Li L, Tan S, Zhu G.   +9 more
europepmc   +1 more source

Ahcy Acts as an Effector of Hnf4a‐Driven Super‐Enhancer Activation to Alleviate MASLD During Intermittent Fasting

Advanced Science, EarlyView.
Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen, Shilin Zhang, Xiaojie Deng, Wenqiang Xie, Fen Xu, Jie Shen, Hua Liang   +6 more
wiley   +1 more source

Inhibitory effect of transfer factor on infection with the novel variant strain of infectious bursal disease virus in chickens. [PDF]

Poult Sci
Zhu K, Chang S, Zhao P, Che C, Ren Z, Cui W, Wang Y, Zhao P.   +7 more
europepmc   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Dietary Tryptophan Enhances Aryl Hydrocarbon Receptor Activation and Reduces Colitis Through Microbial Metabolism. [PDF]

Cell Mol Gastroenterol Hepatol
Rondeau LE, Da Luz BB, Haas D, Muppidi P, Wang X, Dang R, Rueda G, Nardelli A, De Palma G, Sokol H, Bercik P, Caminero A.   +11 more
europepmc   +1 more source

On a space $H\spf$

Hiroshima Mathematical Journal, 1962
Shiraishi, Risai, Hirata, Yukio
openaire   +2 more sources

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Assessment of a new technique for biological augmentation in sternoclavicular joint dislocations: a cadaveric feasibility and biomechanical evaluation. [PDF]

Eur J Trauma Emerg Surg
Somberg O, Förster E, Rosteius T, Bernstorff M, Schildhauer T, Königshausen M.   +5 more
europepmc   +1 more source