Results 61 to 70 of about 735,551 (295)
Scientific ReportsRandomized controlled trials are the gold standard for assessing therapeutic interventions but face challenges in rare diseases due to small sample sizes and heterogeneous conditions.
Aude Allemang-Trivalle +2 more
doaj +1 more source
BMC Medical Research Methodology, 2022 Background Many clinical practice guidelines are based on randomised controlled trials conducted in secondary or tertiary care setting and general practitioners frequently question their relevance for primary care patients.
Amandine Dugard +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Multiple-Symbol Differential Sphere Detection Aided Differential Space-Time Block Codes Using QAM Constellations [PDF]
, 2011 We propose Multiple-Symbol Differential Detection (MSDD) aided Differential Space-Time Block Codes (DSTBCs) using QAM. Our solution eliminates the requirement of high-complexity MIMO channel estimation and its pilot overhead, while mitigating the ...
Wang, Li +7 more
core +2 more sources
Ekonomika Nauki, 2021 Scientific and technical activities in Russia are mainly concentrated in scientific organizations and universities. Taking into account the tasks of improving the mechanisms of public administration in the field of intellectual property, the development ...
A. V. Klypin +3 more
doaj +1 more source
A duality between spheres and spheres with arcs [PDF]
Proceedings of the American Mathematical Society, 1970 The purpose of this paper is to extend the authors duality between nearly tame spheres and nearly tame arcs to a duality between wild spheres and tame spheres with nearly tame arcs properly attached, one arc for each wild point of the wild sphere.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Flow past a sphere at the free-surface using URANS
, 2013 The flow past a sphere located at the free-surface, was studied over the critical Reynolds number range: 2x10^5 to 4x10^5. Experiments were carried out in the Lamont tank at the University of Southampton.
Hudson, D.A., James, M., Turnock, S.R.
core +1 more source
Study on Parameter Choice Methods for the RFMP with Respect to Downward Continuation
Frontiers in Applied Mathematics and Statistics, 2017 Recently, the regularized functional matching pursuit (RFMP) was introduced as a greedy algorithm for linear ill-posed inverse problems. This algorithm incorporates the Tikhonov-Phillips regularization which implies the necessity of a parameter choice ...
Martin Gutting +3 more
doaj +1 more source