Results 1 to 10 of about 59,605 (160)

Sphere‑forming assay vs. organoid culture: Determining long‑term stemness and the chemoresistant capacity of primary colorectal cancer cells. [PDF]

Int J Oncol, 2019
Three‑dimensional (3D) cultures are indispensable for capturing tumor heterogeneity in colorectal cancer (CRC) in vitro. Although 3D cultures (such as sphere‑forming assay and organoid culture) can partially preserve the morphological and molecular characteristics of primary CRC, whether these 3D cultures maintain the long‑term stemness of cancer stem ...
Zhao H, Yan C, Hu Y, Mu L, Huang K, Li Q, Li X, Tao D, Qin J.   +8 more
europepmc   +4 more sources

Sphere-Formation Assay: Three-Dimensional in vitro Culturing of Prostate Cancer Stem/Progenitor Sphere-Forming Cells

Frontiers in Oncology, 2018
Cancer Stem Cells (CSCs) are a sub-population of cells, identified in most tumors, responsible for the initiation, recurrence, metastatic potential, and resistance of different malignancies.
Hisham F. Bahmad, Katia Cheaito, Reda M. Chalhoub, Ola Hadadeh, Alissar Monzer, Farah Ballout, Albert El-Hajj, Deborah Mukherji, Yen-Nien Liu, Georges Daoud, Wassim Abou-Kheir   +10 more
doaj   +3 more sources

METTL3-mediated m6A modification of LINC00857 enhances stemness and metastasis of ovarian cancer cells by activating the YAP-TEAD pathway [PDF]

Scientific Reports
This study was designed to illustrate the mechanism underlying the up-regulation of LINC00857 expression and to identify novel molecular targets for the treatment of ovarian cancer (OC).
Xueke Lin, Yiting Hong, Shengjun You, Ping Li, Yuchun Lv, Jinyang Zheng, Pengming Sun   +6 more
doaj   +2 more sources

Investigating the Effects of ONC206 Alone and in Combination with Cisplatin on Ovarian Cancer Cell Models [PDF]

Current Issues in Molecular Biology
Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide, with high rates of disease relapse posing a significant therapeutic challenge. Consequently, there is an urgent need to develop novel treatments for OC.
Sara Mikhael, Rona Fayyad, Leen Abi Harfouch, Varun Vijay Prabhu, Hisham F. Bahmad, Wassim Abou-Kheir, Georges Daoud   +6 more
doaj   +2 more sources

P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells [PDF]

Discover Oncology
Background Gastric cancer (GC), a prevalent aggressive form of tumor, imposes a significant burden in terms of morbidity and mortality. Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha ...
PeiYao Gao, HengJin Tian, KunPeng Ge, FeiFan Wang, YanMing Zhao, JiWen Sun, Qiang Zhang   +6 more
doaj   +2 more sources

Sub-Sets of Cancer Stem Cells Differ Intrinsically in Their Patterns of Oxygen Metabolism [PDF]

, 2013
PMCID: PMC3640080This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Adrian Biddle, Anne C. Johannessen, DM Brizel, E Gemenetzidis, E Louie, E Sasabe, E Sasabe, G Dontu, GL Semenza, H Wang, H Zhang, H Zhong, Hannah K. Heywood, HK Heywood, I Papandreou, Ian C. Mackenzie, JP Thiery, JW Kim, LJ Harper, LJ Harper, Luke Gammon, M Al-Hajj, M Diehn, M Wartenberg, ME Prince, MF Clarke, MH Yang, MH Yang, MK Ayrapetov, O Warburg, O Warburg, P van Uden, PB Gupta, PD Sutphin, PJ Kallio, Q Li, R Sullivan, RD Lester, SA Mani, SM Wigfield, SS Prime, T Brabletz, T McFate, Yao Liang Tang   +43 more
core   +10 more sources

mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma

Frontiers in Oncology, 2023
Mammary adenocarcinoma, the most common cancer in female dogs, often exhibits the lymph node and lung metastases and has a higher mortality rate. However, mammary adenocarcinoma has no established treatment, except early surgical excision. Canine mammary
Masaki Michishita, Masaki Michishita, Kazuhiko Ochiai, Kazuhiko Ochiai, Rei Nakahira, Daigo Azakami, Yukino Machida, Tomokazu Nagashima, Takayuki Nakagawa, Toshiyuki Ishiwata   +9 more
doaj   +1 more source

Blood exosome marker miRNA-30d-5p: Role and regulation mechanism in cell stemness and gemcitabine resistance of hepatocellular carcinoma

Molecular and Cellular Probes, 2023
Background: Cancer stem cells (CSCs) are different from regular cancer cells because of their self-renewal feature and differentiation potential, which establishes the backbone of the vital role of CSCs in the progress and drug resistance of ...
Biao Tang, Longhui Xie, Xin Tang, Junjie Tian, Shaofei Xiao   +4 more
doaj   +1 more source

Epcam, CD44, and CD49f distinguish sphere-forming human prostate basal cells from a subpopulation with predominant tubule initiation capability. [PDF]

PLoS ONE, 2012
BackgroundHuman prostate basal cells expressing alpha-6 integrin (CD49f(Hi)) and/or CD44 form prostaspheres in vitro. This functional trait is often correlated with stem/progenitor (S/P) activity, including the ability to self-renew and induce ...
Changyong Guo, Haibo Liu, Bao-Hui Zhang, Radu M Cadaneanu, Aqila M Mayle, Isla P Garraway   +5 more
doaj   +1 more source

RETRACTED: A Novel Tumor Suppressor Gene, ZNF24, Inhibits the Development of NSCLC by Inhibiting the WNT Signaling Pathway to Induce Cell Senescence

Frontiers in Oncology, 2021
ObjectiveUnderstanding the characteristics of tumor suppressor genes (TSGs) is of great significance for the development of new targeted treatment strategies for non-small cell lung cancer (NSCLC).
Bo Pang, Yong Wang, Xiaoyan Chang
doaj   +1 more source