Results 21 to 30 of about 59,464 (256)

Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]

, 2017
Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin, Guan, Wei, Hu, Junhui, Liu, Peijun, Qian, Yuan, Sharrow, Allison C, Tang, Kun, Wu, Lily, Xiao, Haibing, Xu, Hua, Ye, Zhangqun   +10 more
core   +3 more sources

Single-Cell Tracking of Breast Cancer Cells Enables Prediction of Sphere Formation from Early Cell Divisions

iScience, 2018
Summary: The mammosphere assay has become widely employed to quantify stem-like cells in a population. However, the problem is there is no standard protocol employed by the field.
Patrick C. Bailey, Rachel M. Lee, Michele I. Vitolo, Stephen J.P. Pratt, Eleanor Ory, Kristi Chakrabarti, Cornell J. Lee, Keyata N. Thompson, Stuart S. Martin   +8 more
doaj   +1 more source

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]

, 2016
The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J., Gomez-Roman, Natividad, McGregor, Fiona, Plumb, Jane   +3 more
core   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources

MicroRNA-214-3p inhibits the stem-like properties of lung squamous cell cancer by targeting YAP1

Cancer Cell International, 2020
Background Emerging evidence reveals that microRNAs (miRNAs) play a crucial role in tumor progression, but the underlying mechanism of microRNAs in lung squamous cell cancer (LSCC) remains unclear.
Tingting Lu, Ying Yang, Ziming Li, Shun Lu   +3 more
doaj   +1 more source

FUS-CHOP promotes invasion in myxoid liposarcoma through a SRC/FAK/RHO/ROCK-dependent pathway [PDF]

, 2017
Deregulated SRC/FAK signaling leads to enhanced migration and invasion in many types of tumors. In myxoid and round cell liposarcoma (MRCLS), an adipocytic tumor characterized by the expression of the fusion oncogene FUS-CHOP, SRC have been found as one ...
González, M. Victoria, Hermida Prado, Francisco, Singh Singh, Ranjit, Tornin Cavielles, Juan   +3 more
core   +2 more sources

Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target

BMC Cancer, 2019
Backgrounds The role of sphere-forming culture in enriching subpopulations with stem-cell properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its value in enriching cancer stem cells (CSCs) subpopulations and the ...
Xiao-Lu Ma, Yun-Fan Sun, Bei-Li Wang, Min-Na Shen, Yan Zhou, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Ya Cao, Bai-shen Pan, Jian Zhou, Jia Fan, Wei Guo, Xin-Rong Yang   +14 more
doaj   +1 more source

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family [PDF]

, 2013
Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions.
A Arvand, A Bertolotti, A Bhattacherjee, A Boro, A Zarrine-Afsar, AB Sigalov, AG Turjanski, AH Mao, AH Mao, AK Dunker, AS Mahadevi, AS Reddy, AS Reddy, AY Tan, BA Shoemaker, C Haynes, D Alex, D Vijay, ED Ross, F Jin, G Gill, GM Lee, Guanghong Wei, HJ Dyson, HS Ashbaugh, HS Chan, HS Chan, Hue Sun Chan, HV Erkizan, HV Erkizan, I Staneva, J Danielsson, J Kim, J Singh, J Wang, J Wang, JC Hansen, JC Ma, JF Rual, Jianhui Song, JMR Baker, JP Gallivan, JP Gallivan, JS Barber-Rotenberg, JS Rao, JW Caldwell, Kevin A. W. Lee, KP Ng, KP Ng, KP Ng, L Feng, LM Iakoucheva, LM Salonen, M Azuma, M Borg, M Fuxreiter, M Levitt, MA Pufall, MS Cortese, MS Marshall, P Nash, P Tompa, P Tompa, PB Crowley, Peter Tompa, PJ Grohar, Q Lu, R Bachmaier, R Janknecht, R Petermann, R Wu, S Abeln, Sheung Chun Ng, SK Burley, SM Butterfield, T Mittag, T Mittag, V Neduva, VJ Hilser, VN Uversky, W Wang, W Zhong, X Chu, X Chu, X Xiu, Y Huang, Y Huang, Y Huang, Z Zhang   +88 more
core   +3 more sources

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway [PDF]

, 2015
Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens.
Drakaki, A, Georgoulias, V, Hatziapostolou, M, Iliopoulos, D, Polytarchou, C, Poultsides, GA, Souglakos, J, Vorvis, C   +7 more
core   +2 more sources