Results 1 to 10 of about 2,109,763 (264)

Sphere-Formation Assay: Three-Dimensional in vitro Culturing of Prostate Cancer Stem/Progenitor Sphere-Forming Cells [PDF]

Frontiers in Oncology, 2018
Cancer Stem Cells (CSCs) are a sub-population of cells, identified in most tumors, responsible for the initiation, recurrence, metastatic potential, and resistance of different malignancies.
Hisham F. Bahmad, Katia Cheaito, Reda M. Chalhoub, Ola Hadadeh, Alissar Monzer, Farah Ballout, Albert El-Hajj, Deborah Mukherji, Yen-Nien Liu, Georges Daoud, Wassim Abou-Kheir   +10 more
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Epcam, CD44, and CD49f distinguish sphere-forming human prostate basal cells from a subpopulation with predominant tubule initiation capability. [PDF]

PLoS ONE, 2012
BackgroundHuman prostate basal cells expressing alpha-6 integrin (CD49f(Hi)) and/or CD44 form prostaspheres in vitro. This functional trait is often correlated with stem/progenitor (S/P) activity, including the ability to self-renew and induce ...
Changyong Guo, Haibo Liu, Bao-Hui Zhang, Radu M Cadaneanu, Aqila M Mayle, Isla P Garraway   +5 more
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mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma

Frontiers in Oncology, 2023
Mammary adenocarcinoma, the most common cancer in female dogs, often exhibits the lymph node and lung metastases and has a higher mortality rate. However, mammary adenocarcinoma has no established treatment, except early surgical excision. Canine mammary
Masaki Michishita, Masaki Michishita, Kazuhiko Ochiai, Kazuhiko Ochiai, Rei Nakahira, Daigo Azakami, Yukino Machida, Tomokazu Nagashima, Takayuki Nakagawa, Toshiyuki Ishiwata   +9 more
doaj   +1 more source

Blood exosome marker miRNA-30d-5p: Role and regulation mechanism in cell stemness and gemcitabine resistance of hepatocellular carcinoma

Molecular and Cellular Probes, 2023
Background: Cancer stem cells (CSCs) are different from regular cancer cells because of their self-renewal feature and differentiation potential, which establishes the backbone of the vital role of CSCs in the progress and drug resistance of ...
Biao Tang, Longhui Xie, Xin Tang, Junjie Tian, Shaofei Xiao   +4 more
doaj   +1 more source

RETRACTED: A Novel Tumor Suppressor Gene, ZNF24, Inhibits the Development of NSCLC by Inhibiting the WNT Signaling Pathway to Induce Cell Senescence

Frontiers in Oncology, 2021
ObjectiveUnderstanding the characteristics of tumor suppressor genes (TSGs) is of great significance for the development of new targeted treatment strategies for non-small cell lung cancer (NSCLC).
Bo Pang, Yong Wang, Xiaoyan Chang
doaj   +1 more source

Sevoflurane Does Not Promote the Colony-Forming Ability of Human Mesenchymal Glioblastoma Stem Cells In Vitro

Medicina, 2022
Background and Objectives: Clinically used concentrations of sevoflurane, an inhaled anesthetic, have been reported to significantly inhibit tumor growth.
Tomohiro Shoji, Mikio Hayashi, Chisato Sumi, Munenori Kusunoki, Takeo Uba, Yoshiyuki Matsuo, Kiichi Hirota   +6 more
doaj   +1 more source

SKP1 promotes YAP-mediated colorectal cancer stemness via suppressing RASSF1

Cancer Cell International, 2020
Background Cancer stem cells (CSCs) have been recognized as an important drug target, however, the underlying mechanisms have not been fully understood. SKP1 is a traditional drug target for cancer therapy, while, whether SKP1 promotes colorectal cancer (
Cong Tian, Tingyuan Lang, Jiangfeng Qiu, Kun Han, Lei Zhou, Daliu Min, Zhiqi Zhang, Dachuan Qi   +7 more
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NCAPG stimulates lung adenocarcinoma cell stemness through aerobic glycolysis

The Clinical Respiratory Journal, 2023
Background Cancer stem cells are pivotal in cancer progression and therapy, including lung adenocarcinoma (LUAD). High NCAPG level is implicated in malignant tumorigenesis, but investigations on NCAPG and LUAD stem cells are warranted.
Zuwang Zhang, Dongdong Qi, Xun Liu, Poming Kang   +3 more
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NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells. [PDF]

PLoS ONE, 2018
Accumulating evidence demonstrated that NANOG1, the key transcription factor for embryonic stem cells, is associated with human cancers. NANOGP8, one of the pseudogenes in NANOG gene family, contains an intact open reading frame and also said to be ...
Xia Ma, Bei Wang, Xiaofang Wang, Yujiao Luo, Wufang Fan   +4 more
doaj   +1 more source

In vitro analysis of breast cancer cell line tumourspheres and primary human breast epithelia mammospheres demonstrates inter- and intrasphere heterogeneity.

PLoS ONE, 2013
Mammosphere and breast tumoursphere culture have gained popularity as in vitro assays for propagating and analysing normal and cancer stem cells. Whether the spheres derived from different sources or parent cultures themselves are indeed single entities ...
Chanel E Smart, Brian J Morrison, Jodi M Saunus, Ana Cristina Vargas, Patricia Keith, Lynne Reid, Leesa Wockner, Marjan Askarian-Amiri, Debina Sarkar, Peter T Simpson, Catherine Clarke, Chris W Schmidt, Brent A Reynolds, Sunil R Lakhani, J Alejandro Lopez   +14 more
doaj   +1 more source