Results 1 to 10 of about 4,918 (194)

Citicoline May Effectively Reduce Hard Exudates in Diabetic Retinopathy [PDF]

Biomedicines
Background/Objectives: Diabetic retinopathy (DR) develops from the interplay of vascular, inflammatory, and neurodegenerative processes. Citicoline, a natural compound essential for cell membranes, enhances neurotransmitter levels, has a neuroprotective ...
Martina Tomić, Toma Babić, Tomislav Bulum, Spomenka Ljubić, Tomislav Jukić   +4 more
doaj   +3 more sources

The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation [PDF]

Scientific Reports
Head irradiation is a common treatment for brain cancer; however, it can cause side effects in healthy brain tissue. This study aimed to test whether citicoline administration modulates radiation-induced brain mitochondrial dysfunction in rats.
Nahed Abdel-Aziz, Fatma Rabia Algeda, Shereen M. Shedid   +2 more
doaj   +4 more sources

Combined citicoline and Cerebrolysin for neuroprotection in traumatic brain injury: a retrospective cohort analysis [PDF]

Frontiers in Neurology
IntroductionSevere traumatic brain injury (sTBI) remains a major cause of long-term disability and mortality worldwide. Beyond the initial mechanical damage, a cascade of secondary injuries involving neuroinflammation, oxidative stress, and ...
Philipp Schlager, Philipp Schlager, Ivan Grgac, Ivan Grgac, Guenther Herzer, Guenther Herzer, Helmut Trimmel, Helmut Trimmel, Helmut Trimmel   +8 more
doaj   +4 more sources

Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis [PDF]

Frontiers in Neurology
BackgroundOver 44 million people worldwide live with dementia, affecting their quality of life and well-being. Choline alphoscerate and citicoline supplements are commonly used to improve cognitive function in dementia patients.
Getu Gamo Sagaro, Getu Gamo Sagaro, Francesco Amenta, Francesco Amenta   +3 more
doaj   +4 more sources

The efficacy of different doses of citicoline in improving the prognosis of patients with acute ischemic stroke based on network meta-analysis [PDF]

Frontiers in Pharmacology
ObjectiveOur group aimed to explore the effect of different dosages of citicoline on ischemic stroke (IS) patients and determine the most appropriate dosage for these patients.MethodsThe databases of PubMed, Cochrane Library, Medline, Web of Science, and
Xu Zhao, Xianhao Huo, Yizhen Meng, Ran Zhao, Xiaozhuo Liu, Jiancheng Chen, Zhiqi Mao, Mei Li   +7 more
doaj   +2 more sources

Citicoline for the Management of Patients with Traumatic Brain Injury in the Acute Phase: A Systematic Review and Meta-Analysis [PDF]

Life, 2023
Background: Citicoline or CDP-choline is a neuroprotective/neurorestorative drug used in several countries for the treatment of traumatic brain injury (TBI).
Julio José Secades, Helmut Trimmel, Byron Salazar, José Antonio González   +3 more
doaj   +2 more sources

Effects of citicoline administration on synaptic proteins in rapid eye movement sleep-deprived rats [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Sleep has a pivotal role in learning-memory and sleep deprivation (SD) negatively affects synaptic functioning. Cytidine-5-diphosphocholine (Citicoline) has been known to improve learning and memory functions.
Ayşen Cakir, Busra Ocalan, Cansu Koc, Guldal Gulec Suyen, Mehmet Cansev, Nevzat Kahveci   +5 more
doaj   +3 more sources

Citicoline Triggers Proteome Remodeling and Proteostatic Adaptation: Evidence from Shotgun Proteomics [PDF]

Pharmaceutics
Background/Objectives: Citicoline, also known as CDP-choline, is a nootropic agent currently used in the treatment of glaucoma and is undergoing evaluation as a first-line therapy in a multi-center, international, phase III, randomized clinical trial ...
Dario Cavaterra, Sara Giammaria, Irene Pandino, Gabriele Antonio Zingale, Valerio Delli Paoli, Rebecca Fiore, Manuele Michelessi, Gloria Roberti, Carmela Carnevale, Lucia Tanga, Daniela Cazzato, Elisa Peroni, Giuseppe Grasso, Gianluca Manni, Alessio Bocedi, Francesco Oddone, Massimiliano Coletta, Diego Sbardella, Grazia Raffaella Tundo   +18 more
doaj   +2 more sources

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution.

PLoS ONE, 2019
PURPOSE:To evaluate the presence and concentration of citicoline and its metabolites (choline, cytidine and uridine) in the vitreous body in human eyes after topical application of an ophthalmic solution of citicoline 2%, in vivo.
Carmela Carnevale, Gianluca Manni, Gloria Roberti, Alessandra Micera, Luca Bruno, Andrea Cacciamani, Romeo Altafini, Luciano Quaranta, Luca Agnifili, Lucia Tanga, Ivano Riva, Francesco Oddone   +11 more
doaj   +3 more sources

The effect of citicoline administration on visual function improvement in stroke patients at Prof. Dr. Chairuddin Panusunan Lubis Hospital, University of Sumatera Utara, and affiliated network hospitals [PDF]

Frontiers in Medicine
BackgroundVisual disturbances are a common and often debilitating complication following stroke, significantly impairing patients’ functional independence and quality of life. Among various neuroprotective agents, Citicoline (cytidine-5′-diphosphocholine)
Silvia Fransisca, Bobby Ramses Erguna Sitepu, Delfi   +2 more
doaj   +2 more sources