Results 31 to 40 of about 4,987 (254)

Citicoline for Supporting Memory in Aging Humans

Aging and disease, 2022
Citicoline is the generic name of CDP-choline, a natural metabolite presents in all living cells. Used in medicine as a drug since the 1980-s, citicoline was recently pronounced a food ingredient. When ingested, citicoline breaks down to cytidine and choline, which become incorporated into their respective normal metabolic pathways.
Świątkiewicz, Maciej, Grieb, Paweł
openaire   +2 more sources

Impact of neuroprotective therapy on cognition and oxidative stress in the early stages of Parkinson’s disease

Patologìâ, 2021
The aim of this study was to investigate the clinical and biochemical efficiency of citicoline in cognitive improvement and changes of glutathione peroxidase (GPx) blood plasma levels in patients at early stages of Parkinson’s disease (PD).
A. V. Demchenko, V. V. Biriuk
doaj   +1 more source

Serum Hsp70 antigen: Early diagnosis marker in perinatal asphyxia [PDF]

, 2015
BACKGROUND: Perinatal asphyxia is an important cause of mortality and permanent neurological and developmental deficit. Early and accurate diagnosis would help to establish the likely prognosis and may also help in determining the most appropriate ...
Boskabadi, Hassan, Ferns, Gordon A A, Mobarhan, Majid Ghayour, Mohammadi, Shabnam, Omidian, Masoud, Parizadeh, Mostafa, Tavallai, Shima   +6 more
core   +1 more source

Citicoline: A Candidate for Adjunct Treatment of Multiple Sclerosis [PDF]

Pharmaceuticals, 2021
In remitting–relapsing multiple sclerosis (RR-MS), relapses are driven by autoreactive immune cells that enter the brain and spinal cord and damage myelin sheaths of axons in white and grey matter, whereas during remissions myelin is repaired by activated oligodendroglial cells.
Paweł Grieb, Maciej Świątkiewicz, Agnieszka Kamińska, Anselm Jünemann, Robert Rejdak, Konrad Rejdak   +5 more
openaire   +4 more sources

Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials [PDF]

, 2005
<p><b>Background and Purpose:</b> Acute stroke trials typically use disability scales as their primary end point. Neurologic impairment scales such as the National Institutes of Health Stroke Scale (NIHSS) are possibly more sensitive to
Lees, K.R., Weir, C.J., Young, F.B.
core   +1 more source

Citicoline: neuroprotective mechanisms 
in cerebral ischemia [PDF]

Journal of Neurochemistry, 2001
AbstractCytidine‐5′‐diphosphocholine (citicoline or CDP‐choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown beneficial effects in a number of CNS injury models and pathological conditions of the brain. Citicoline improved the outcome in several phase‐III clinical trials of stroke, but provided inconclusive results ...
Rao Muralikrishna, Adibhatla, J F, Hatcher, R J, Dempsey   +2 more
openaire   +2 more sources

Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review [PDF]

Pharmaceuticals, 2021
Cytidine 5’-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its ...
Francesco Oddone, Luca Rossetti, Mariacristina Parravano, Diego Sbardella, Massimo Coletta, Lucia Ziccardi, Gloria Roberti, Carmela Carnevale, Dario Romano, Gianluca Manni, Vincenzo Parisi   +10 more
openaire   +4 more sources

Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia

Journal of Pharmacological Sciences, 2019
Phospholipids are structural components of cellular membranes that play important roles as precursors for various signaling pathways in modulating neuronal membrane function and maintenance of the intracellular environment.
Eri Nakazaki, Yasushi Yabuki, Hisanao Izumi, Yasuharu Shinoda, Fumiko Watanabe, Yukihiro Hishida, Ayako Kamimura, Kohji Fukunaga   +7 more
doaj   +1 more source

Evidence of the neuroprotective role of citicoline in glaucoma patients [PDF]

, 2008
The glaucomatous disease is currently considered a disease involving ocular and visual brain structures. This new approach to glaucoma introduces the possibility of inducing an improvement by means of a pharmacological approach similar to that used in ...
Armington, Bach, Birbamer, Boismare, Cacabelos, Campos, Celesia, Celesia, Chaturvedi, Colotto, Fiorentini, Garway-Heath, Goracci, Gottlob, Gottlob, Gottlob, Graham, Greenstein, Gupta, Gur, Holder, Horn, Kakihana, Kennedy, Klistorner, Leguire, Maffei, Martus, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Parisi, Pecori-Giraldi, Porciatti, Porciatti, Rejdak, Salgarello, Secades, Serra, Vaegan, Ventura, Ventura, Virno, Watanabe, Weber, Weiss, Yucel, Yucel   +55 more
core   +1 more source

Citicoline Modifies the Expression of Specific miRNAs Related to Cardioprotection in Patients with ST-Segment Elevation Myocardial Infarction Subjected to Coronary Angioplasty

Pharmaceuticals, 2022
Extracellular vesicles are recognized as signaling mediators between cells both in physiological and pathological communication. In this work, we explored the potential effect of citicoline to modify relevant proteins or miRNAs for cardioprotection in ...
Alejandro Silva-Palacios, Miguel Arroyo-Campuzano, Mirthala Flores-García, Mariana Patlán, Adrián Hernández-Díazcouder, Diego Alcántara, Ixchel Ramírez-Camacho, Dana Arana-Hidalgo, Elizabeth Soria-Castro, Fausto Sánchez, Héctor González-Pacheco, Cecilia Zazueta   +11 more
doaj   +1 more source