Results 51 to 60 of about 2,761 (203)

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Citicoline Ameliorates Neuro- and Genotoxicity Induced by Acute Malathion Intoxication in Rats [PDF]

Journal of Bioscience and Applied Research, 2019
Objective: In the present study, we explored the therapeutic potential of citicoline in preventing malathion induced neurotoxicity and genotoxicity. Citicoline has been shown to act as a neuroprotective in experimental animal models of ischemia and other
Asmaa Galal, Lamiaa Salem, Mahrousa Hassanane, Somaia Nada, Omar Abdel-Salam   +4 more
doaj   +1 more source

Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Mild cognitive impairment (MCI) carries a risk of further cognitive decline; thus, early diagnosis and intervention are important. The ASCEND Expert Group presents novel algorithms for (1) cognitive assessment/clinical diagnosis and (2) MCI management, emphasizing a multimodal strategy encompassing metabolic/cerebrovascular risk reduction, sensory loss
Nagaendran Kandiah, Yee Fai Chan, Darwin Dasig, Jacqueline Dominguez, Kar Chai Koh, Si Ching Lim, Paulus Anam Ong, Encarnita Raya‐Ampil, Raymond Chee Seong Seet, Vorapun Senanarong, Kit Mun Tan, Maw Pin Tan, Trần Công Thắng, Tong Mai Trang, Yuda Turana, Cuibai Wei, Ralf Ihl   +16 more
wiley   +1 more source

Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution - Fig 1

, 2019
(A-E). Representative chromatogram of a mixture of citicoline and metabolites. Representative chromatogram of a mixture of citicoline and metabolites.
Andrea Cacciamani (7866326), Romeo Altafini (7866329), Lucia Tanga (786589), Gianluca Manni (781382), Gloria Roberti (815919), Ivano Riva (4540321), Carmela Carnevale (6280860), Alessandra Micera (294762), Luca Bruno (7866323), Luciano Quaranta (3625409), Francesco Oddone (786588), Luca Agnifili (3625406)   +11 more
core   +1 more source

Lipid Metabolism in Central Nervous System Diseases: Pathological Mechanisms and Therapeutic Advances

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Dysregulated lipid metabolism in CNS diseases: core mechanisms and targeted interventions. Lipid metabolism dysregulation participates in the pathological progression of neurodegenerative diseases, traumatic CNS injuries and cerebrovascular diseases by mediating key pathological processes including abnormal protein aggregation, neuroinflammation, lipid
Jiayan Yuan, Shixue Huang, Kun Jiao, Shu Yang, Xuhui Ge, Wei Liu, Wei Wang, Haoming Shu, Xuhui Zhou   +8 more
wiley   +1 more source

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

Epilepsia Open, Volume 11, Issue 4, Page 1095-1110, August 2026.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini, Arunachalam Divya, Kumar Sowndharya, Parthiban Jeevitha, Selvam Manoj, Ashiq Rahman, Athil Ahamed, Ravichandiran Abirahul, Paranthaman Subash, Sulekha Khute   +9 more
wiley   +1 more source

An Open-label Randomized Crossover Study with Adaptive Design of the Pharmacokinetics and Bioequivalence of GP30121 and Ceraxon® Corrected for Endogenous Analyte Level

Разработка и регистрация лекарственных средств, 2023
Introduction. Citicoline is an endogenous nucleoside consisting of cytidine and choline linked by a diphosphate bridge that is involved in the synthesis of membrane phospholipids.
A. N. Arevefa, A. R. Dorotenko, S. M. Noskov, I. E. Makarenko, R. V. Drai, T. N. Komarov, O. A. Archakova, N. S. Bagaeva, I. E. Shokhin   +8 more
doaj   +1 more source

Comparison of citicoline versus the control group.

, 2023
Comparison of citicoline versus the control group.
Matthias Fuest (3158196), Julia Prinz (1234245), Hanhan Liu (568151), Peter Walter (4403), Filippo Migliorini (9032144), Verena Prokosch (316871)   +5 more
core   +1 more source

Acute pain transfusion reaction in a patient with thalassemia: In‐depth characterization of short‐ and long‐term phenotypes

Transfusion, Volume 66, Issue 7, Page 1299-1315, July 2026.
Abstract Background Acute pain transfusion reaction (APTR) is a rare, under‐recognized condition of unknown etiology. It can cause significant distress in recipients, necessitating symptomatic management and, occasionally, hospitalization. Study Design and Methods Here, we present an APTR event in an adult subject with transfusion‐dependent thalassemia
Georgia Tzafa, Sophia Delicou, Ioanna Barla, Konstantina Theocharaki, Aggeliki Kondi, Athanassios D. Velentzas, Nikolaos Simantiris, Elli‐Anna Stylianaki, George Mpekoulis, Efthymia Pavlou, Niki Vassilaki, Ioannis V. Kostopoulos, Aikaterini Xydaki, Efrosyni Nomikou, Ioanna‐Katerina Aggeli, Nikolaos Thomaidis, Evangelos Gikas, Martina Samiotaki, Jerome Zoidakis, Constantina Politis, Marianna H. Antonelou   +20 more
wiley   +1 more source

Baseline comparability of the citicoline and the control group.

, 2023
Baseline comparability of the citicoline and the control group.
Matthias Fuest (3158196), Julia Prinz (1234245), Hanhan Liu (568151), Peter Walter (4403), Filippo Migliorini (9032144), Verena Prokosch (316871)   +5 more
core   +1 more source