Results 71 to 80 of about 2,761 (203)

Efficacy of citicoline as a supplement in glaucoma patients: A systematic review.

PLoS ONE, 2023
PurposeGlaucoma is a leading cause of irreversible blindness worldwide. Retinal ganglion cells (RGC), the neurons that connect the eyes to the brain, specifically die in glaucoma, leading to blindness.
Julia Prinz, Verena Prokosch, Hanhan Liu, Peter Walter, Matthias Fuest, Filippo Migliorini   +5 more
doaj   +1 more source

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure

Trials
Background The SARS CoV-2 pandemic has resulted in more than 1.1 million deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are limited.
Sonal Pannu, Matthew C. Exline, Joseph S. Bednash, Joshua A. Englert, Philip Diaz, Amy Bartlett, Guy Brock, Qing Wu, Ian C. Davis, Elliott D. Crouser   +9 more
doaj   +1 more source

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

Effectiveness of Citicoline versus Citicoline with Piracetam in Moderate to Severe Acute Ischemic Stroke Patients: A Quasi Experimental Prospective Study [PDF]

Stroke is a sudden cerebral root neurologic collapse, a major cause for global morbidity and death, necessitates the use of neuroprotectants to prevent further damage to ischemic decline.
Ramesh, Anusha, Muralidharan, Madhumidha, Saravanan, Prarthana, Murugesan, Karthick, Sivadasan, Shalini, Elumalai, Senthil Kumar   +5 more
core   +1 more source

Relative Efficacy of Piracetam, Modafinil and Citicoline on Cognitive Function in an Animal Model [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Nootropic drugs or cognitive enhancers are pharmacological agents that improve cognitive function and memory by various mechanisms. Drugs like piracetam, modafinil and citicoline have been used as nootropic agents.
Farrukh Ahmad, Veena Nayak, Chaitanya Malalur, Rinz Mathew, Amruta Tripathy, Kurady Laxminarayana Bairy   +5 more
doaj   +1 more source

From Regeneration Failure to Functional Restoration: Unlocking the Neuronal‐Intrinsic Regenerative Capacity as a Therapeutic Frontier for Optic Neuropathy and Glaucoma

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
Optic neuropathy and glaucoma cause permanent visual deficits via retinal ganglion cell (RGC) loss and axon degeneration, affecting millions worldwide. Current treatments slow disease progression but cannot restore lost vision due to regeneration failure in adult RGCs.
Emma Beard, Safa El‐Bushra, Zahra Kader, Yujiao Jennifer Sun, Ngan Pan Bennett Au   +4 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, Volume 99, Issue 1, Page 19-34, January 2026.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Comorbidity of Attention Deficit Hyperactivity Disorder (ADHD) and Chung‐Jansen Syndrome: Case Report and Review of Literature

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Chung‐Jansen Syndrome (CJS) is a rare autosomal dominant neurodevelopmental disorder caused by heterozygous mutations in the PHIP gene (6q14.1). It is characterized by developmental delay, intellectual disability, behavioral disturbances including autism spectrum disorder and attention deficit hyperactivity disorder, obesity, and distinct ...
Maedeh Khalili, Maryam Yousefi Fahadani, Reza Bidaki, Zahra Talayi   +3 more
wiley   +1 more source

The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives [Corrigendum]

, 2015
Gareri P, Castagna A, Cotroneo AM, Putignano S, De Sarro G, Bruni AC. Clin Interv Aging. 2015;10:1421–1429.On page 1423, Figure 2 Citicoline’s metabolic pathways, please note that this figure has been modified to include: Adibhatla RM ...
Putignano S, De Sarro G, Gareri P, Bruni AC, Castagna A, Cotroneo AM   +5 more
core  

Prevention of epidural fibrosis in rats by local or systemic administration of citicoline [PDF]

, 2012
AIM: The objective of this study was to investigate the effect of citicoline administration on epidural fibrosis which is a frequent complication of lumbar disc surgery with no effective treatment or preventive surgical technique.
Ulus, İsmail Hakkı
core   +1 more source