Results 81 to 90 of about 4,987 (254)

Neuroprotection in stroke: past, present, and future. [PDF]

, 2014
Stroke is a devastating medical condition, killing millions of people each year and causing serious injury to many more. Despite advances in treatment, there is still little that can be done to prevent stroke-related brain damage.
Majid, A.
core   +3 more sources

Prevalence and factors associated with seizures among patients with dementia: A retrospective clinic‐based study

Epilepsia Open, Volume 10, Issue 3, Page 717-724, June 2025.
Abstract Objective Chronic diseases associated with aging, such as dementia and seizures, are expected to rise significantly in the Philippines' growing elderly population. This study aims to determine the frequency, demographic characteristics, and clinical profile of dementia patients who developed new‐onset seizures in an outpatient setting ...
Liz Edenberg Quiles, Prima Kristina Paola Quintay, Adrian Espiritu, Viel Mendoza, Veeda Michelle Anlacan   +4 more
wiley   +1 more source

SCARLET (Supplemental Citicoline Administration to Reduce Lung injury Efficacy Trial): study protocol for a single-site, double-blinded, placebo-controlled, and randomized Phase 1/2 trial of i.v. citicoline (CDP-choline) in hospitalized SARS CoV-2-infected patients with hypoxemic acute respiratory failure

Trials
Background The SARS CoV-2 pandemic has resulted in more than 1.1 million deaths in the USA alone. Therapeutic options for critically ill patients with COVID-19 are limited.
Sonal Pannu, Matthew C. Exline, Joseph S. Bednash, Joshua A. Englert, Philip Diaz, Amy Bartlett, Guy Brock, Qing Wu, Ian C. Davis, Elliott D. Crouser   +9 more
doaj   +1 more source

Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress

Basic and Clinical Neuroscience, 2020
Introduction: Psychomotor performance task is used to assess the arousal and cognitive functions of the central nervous system. Alternatively, human visual working memory reflects the capability of the individual’s short-term memory.
Hayder M. Al-kuraishy, Ali I. Al-Gareeb
doaj  

Hypoxia/Aglycemia-induced endothelial barrier dysfunction and tight junction protein downregulation can be ameliorated by citicoline. [PDF]

PLoS ONE, 2013
This study explores the effect of citicoline on the permeability and expression of tight junction proteins (TJPs) in endothelial cells under hypoxia/aglycemia conditions.
Xiaotang Ma, Huiting Zhang, Qunwen Pan, Yuhui Zhao, Ji Chen, Bin Zhao, Yanfang Chen   +6 more
doaj   +1 more source

Does taking vitamin, mineral and fatty acid supplements prevent cognitive decline? A systematic review of randomized controlled trials [PDF]

, 2008
Background Observational studies have shown associations between nutritional status and cognition in later life but evidence from intervention studies is unclear.
Avenell, Alison, Jia, X, McNeill, G
core   +1 more source

Neuroprotection for neonatal hypoxic–ischemic encephalopathy: A review of novel therapies evaluated in clinical studies

Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.
Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan, Cheryl C. Hawkins, Benjamin V. Rodrigues, Marie‐Coralie Cornet, Fernando F. Gonzalez, Yvonne W. Wu   +5 more
wiley   +1 more source

‘Citicoline’ and support of the memory function: Evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

EFSA Journal
Following an application from Egde Pharma Sp. z o.o, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Poland, the EFSA Panel on Nutrition, Novel Foods and Food ...
EFSA Panel on Nutrition, Novel Foods and Food allergens (NDA), Dominique Turck, Torsten Bohn, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Frank Thies, Sophia Tsabouri, Marco Vinceti, Jean‐Louis Bresson, Thibault Fiolet, Alfonso Siani   +17 more
doaj   +1 more source

Dementia in a resource‐constrained sub‐Saharan African setting: A comprehensive retrospective analysis of prevalence, risk factors, and management at the only neuropsychiatric facility in Northeastern Nigeria

Alzheimer's &Dementia, Volume 21, Issue 3, March 2025.
Abstract INTRODUCTION Dementia prevalence is increasing in sub‐Saharan Africa, potentially due to population growth and aging. Resource‐constrained settings such as Northeastern Nigeria face challenges in dementia management. METHODS We assessed dementia burden and management at the Federal Neuropsychiatric Hospital Maiduguri, the only neuropsychiatric
Ibrahim Abdu Wakawa, Umar Baba Musami, Suleiman Hamidu Kwairanga, Placidus Nwankuba Ogualili, Mohammed Yusuf Mahmood, Muhammad Abba Fugu, Mohammed Mala Gimba, Muktar Mohammed Allamin, Zaharadeen Umar Abbas, Muhammad Kawu Sunkani, Zainab Bukar Yaganami, Fatima Mustapha Kadau, Nasir Muhammad Sani, Peter Danmallam, Luka Nanjul, Larema Babazau, Zaid Muhammad, Baba Waru Goni, Babagana Kundi Machina, Celeste M. Karch, Chinedu Udeh‐Momoh, Thomas K. Karikari, Chiadi U. Onyike, Mahmoud Bukar Maina   +23 more
wiley   +1 more source

A Hypothesis: Metabolic Contributions to 16p11.2 Deletion Syndrome

BioEssays, Volume 47, Issue 3, March 2025.
16p11.2 Deletion syndrome is associated with brain, body, and behavioral symptoms. A majority of 16p11.2 genes relate to metabolism, involving amino acids/proteins, DNA, RNA, catabolism, lipids, and carbohydrates. Additional contributions include changes in cell structure, signaling, development, immune system, nervous system, and localization.
Brandon Kar Meng Choo, Sarah Barnes, Hazel Sive   +2 more
wiley   +1 more source