Results 81 to 90 of about 359,437 (296)

Knocking down RAD51AP1 enhances chemosensitivity by inhibiting the self-renewal of CD133 positive ovarian cancer stem-like cells

Discover Oncology
Purpose This study was designed to investigate the function of RAD51AP1 in the self-renewal and chemosensitivity of CD133 positive (CD133+) ovarian cancer (OC) stem-like cells.
Si-heng Zeng, Zhi-qiang Yan, Qing Ren, Li-hui Lin, Zhen Chen   +4 more
doaj   +1 more source

Recurrent progressive anterior segment fibrosis syndrome following a descemet-stripping endothelial keratoplasty in an infant with congenital aniridia

Indian Journal of Ophthalmology, 2014
Progressive anterior segment fibrosis syndrome (ASFS), after intraocular surgery in older children (≥9 years) and adults with congenital aniridia, is described in the literature.
Mihir Kothari, Kavita Rao, Samita Moolani   +2 more
doaj   +1 more source

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]

, 2016
In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
Arrar, Mehrnoosh, Berguer, Paula Mercedes, Cerutti, Maria Laura, Estrin, Dario Ariel, Goldbaum, Fernando Alberto, Klinke, Sebastian, Marti, Marcelo Adrian, Paris, Gastón, Rinaldi, Jimena Julieta, Sycz, Gabriela   +9 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak

Indian Journal of Ophthalmology, 2014
Context: Contrast sensitivity (CS) function is one of the most important tests available for evaluating visual impairment. Multiple sclerosis (MS) can produce highly selective losses in visual function and psychophysical studies have demonstrated CS ...
A F Nunes, P M L Monteiro, M Vaz Pato
doaj   +1 more source

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes [PDF]

, 2016
A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised.
Archibald, Stephen J., Burke, Benjamin P., Miller-Shakesby, David M., Nigam, Shubhanchi, Prior, Timothy J., Redshaw, Carl, Stasiuk, Graeme J.   +6 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Comparative evaluation of RetCam vs. gonioscopy images in congenital glaucoma

Indian Journal of Ophthalmology, 2014
Purpose: To compare clarity, exposure and quality of anterior chamber angle visualization in congenital glaucoma patients, using RetCam and indirect gonioscopy images. Design: Cross-sectional study Participants. Congenital glaucoma patients over age of 5
Raj V Azad, Parijat Chandra, Anuradha Chandra, Aparna Gupta, Viney Gupta, Ramanjit Sihota   +5 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Restoration of Radiosensitivity by Soya Isoflavone Genistein is Accomplished by Facilitating DNA Damage Response in Radioresistant Cervical Cancer in vitro

Journal of Radiation and Cancer Research
Context: Enhancing radiotherapeutic efficacy in tumor cells and sparing the normal tissues are major clinical concerns for the betterment of cancer therapy.
Das Salini, Thakur Debanjan, Sengupta Debomita, Mukherjee Sutapa   +3 more
doaj   +1 more source