Results 71 to 80 of about 59,464 (256)

Knocking down RAD51AP1 enhances chemosensitivity by inhibiting the self-renewal of CD133 positive ovarian cancer stem-like cells

Discover Oncology
Purpose This study was designed to investigate the function of RAD51AP1 in the self-renewal and chemosensitivity of CD133 positive (CD133+) ovarian cancer (OC) stem-like cells.
Si-heng Zeng, Zhi-qiang Yan, Qing Ren, Li-hui Lin, Zhen Chen   +4 more
doaj   +1 more source

Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak

Indian Journal of Ophthalmology, 2014
Context: Contrast sensitivity (CS) function is one of the most important tests available for evaluating visual impairment. Multiple sclerosis (MS) can produce highly selective losses in visual function and psychophysical studies have demonstrated CS ...
A F Nunes, P M L Monteiro, M Vaz Pato
doaj   +1 more source

Analyzing the Catalytic Mechanism of the Fe-Type Nitrile Hydratase from \u3cem\u3eComamonas testosteroni\u3c/em\u3e Ni1 [PDF]

, 2008
In order to gain insight into the catalytic mechanism of Fe-type nitrile hydratases (NHase), the pH and temperature dependence of the kinetic parameters kcat, Km, and kcat/Km along with the solvent isotope effect were examined for the Fe-type NHase from ...
Holz, Richard C., Rao, Saroja
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Comparative evaluation of RetCam vs. gonioscopy images in congenital glaucoma

Indian Journal of Ophthalmology, 2014
Purpose: To compare clarity, exposure and quality of anterior chamber angle visualization in congenital glaucoma patients, using RetCam and indirect gonioscopy images. Design: Cross-sectional study Participants. Congenital glaucoma patients over age of 5
Raj V Azad, Parijat Chandra, Anuradha Chandra, Aparna Gupta, Viney Gupta, Ramanjit Sihota   +5 more
doaj   +1 more source

Synthesis, structures and cytotoxicity studies of p-sulfonatocalix[4]arene lanthanide complexes [PDF]

, 2016
A number of p-sulfonatocalix[4]arene complexes of the lanthanides (Tb, Gd, and Eu) have been prepared, some in the presence of tetraazamacrocycle 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (DO3A), and fully characterised.
Archibald, Stephen J., Burke, Benjamin P., Miller-Shakesby, David M., Nigam, Shubhanchi, Prior, Timothy J., Redshaw, Carl, Stasiuk, Graeme J.   +6 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Brachytherapy of intra ocular tumors using ′BARC I-125 Ocu-Prosta seeds′: An Indian experience

Indian Journal of Ophthalmology, 2014
Aim: To report our experience of brachytherapy using ′BARC I-125 Ocu-Prosta seeds′ for the management of intraocular tumors with regard to tumor control, globe preservation visual outcome, and patient survival at Sankara Nethralaya, Chennai, India ...
Vikas Khetan, Lingam Gopal, Mahesh P Shanmugam, Aditi Gupta, Tarun Sharma, Pramod Bhende, Siva Muthukumar, R Subramaniam, Thayalan Kuppuswamy, S K Saxena, Ashutosh Dash   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Restoration of Radiosensitivity by Soya Isoflavone Genistein is Accomplished by Facilitating DNA Damage Response in Radioresistant Cervical Cancer in vitro

Journal of Radiation and Cancer Research
Context: Enhancing radiotherapeutic efficacy in tumor cells and sparing the normal tissues are major clinical concerns for the betterment of cancer therapy.
Das Salini, Thakur Debanjan, Sengupta Debomita, Mukherjee Sutapa   +3 more
doaj   +1 more source