Results 51 to 60 of about 59,464 (256)

LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer [PDF]

, 2019
Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here,
Fukushima, Kohshiro, Fukuzawa, Moe, Longmore, Gregory D, Mukai, Satomi, Naito, Yoko, Nojima, Hiroshi, Nozaki, Masami, Okamoto, Ayumi, Sasakura, Towa, Yabuta, Norikazu   +9 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A method for detecting stemness of glioblastoma: 3D-tumor spheroid assay

Stem Cell Research
Glioblastoma is one of the most common primary malignant brain tumors, characterized by high aggressiveness and chemoresistance. Glioma stem like cells (GSCs) are recognized as critical drivers of tumor initiation, intratumoral heterogeneity, and ...
Yan Chen, Hao Zeng, Kaixiang Ni, Jiantong Jiao, Songtao Qi   +4 more
doaj   +1 more source

Complications and management in Descemet′s stripping endothelial keratoplasty: Analysis of consecutive 430 cases

Indian Journal of Ophthalmology, 2014
Purpose: To analyze the complications and their managements in Descemet′s stripping endothelial keratoplasty (DSEK) in consecutive 430 cases by single surgeon in a tertiary eye hospital.
Samar K Basak, Soham Basak
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparison on testability of visual acuity, stereo acuity and colour vision tests between children with learning disabilities and children without learning disabilities in government primary schools

Indian Journal of Ophthalmology, 2014
Context: Children with learning disabilities might have difficulties to communicate effectively and give reliable responses as required in various visual function testing procedures.
Nurul Farhana Abu Bakar, Ai-Hong Chen
doaj   +1 more source

Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain [PDF]

, 2016
In response to light, as part of a two-component system, the Brucella blue light-activated histidine kinase (LOV-HK) increases its autophosphorylation, modulating the virulence of this microorganism.
Arrar, Mehrnoosh, Berguer, Paula Mercedes, Cerutti, Maria Laura, Estrin, Dario Ariel, Goldbaum, Fernando Alberto, Klinke, Sebastian, Marti, Marcelo Adrian, Paris, Gastón, Rinaldi, Jimena Julieta, Sycz, Gabriela   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. [PDF]

, 2017
EGFR amplification in cells having double minute chromosomes (DM) is commonly found in glioblastoma multiforme (GBM); however, how much it contributes to the current failure to treat GBM successfully is unknown.
Atkin, Naomi, Chen, Yumay, Gau, Alex, Giedzinski, Erich, Hu, Yuanjie, Lee, Nathan, Limoli, Charles, Linskey, Mark E, Ly, Khang Chi, Pan, Francine, Qiao, Jiao, Ru, Ning, Siegel, Eric R, Tran, Katherine, Wang, Ping, Yu, Liping, Zhou, Yi-Hong   +16 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source