Results 51 to 60 of about 2,109,763 (264)

P4HA1 is highly expressed in gastric cancer and promotes proliferation and metastasis of gastric cancer cells

Discover Oncology
Background Gastric cancer (GC), a prevalent aggressive form of tumor, imposes a significant burden in terms of morbidity and mortality. Prolyl 4-hydroxylase, alpha polypeptide I (P4HA1), a key enzyme in collagen synthesis, comprises two identical alpha ...
PeiYao Gao, HengJin Tian, KunPeng Ge, FeiFan Wang, YanMing Zhao, JiWen Sun, Qiang Zhang   +6 more
doaj   +1 more source

Successful transportation of human corneal endothelial tissues without cool preservation in varying Indian tropical climatic conditions and in vitro cell expansion using a novel polymer

Indian Journal of Ophthalmology, 2014
Background: Though the transplantation of human corneal endothelial tissue (CET) separated from cadaver cornea is in practice, its transportation has not been reported.
Srinivas K Rao, John Sudhakar, Periyasamy Parikumar, Sundaram Natarajan, Aditya Insaan, Hiroshi Yoshioka, Yuichi Mori, Shigeo Tsukahara, Subramani Baskar, Sadananda Rao Manjunath, Rajappa Senthilkumar, Paramasivam Thamaraikannan, Thangavelu Srinivasan, Senthilkumar Preethy, Samuel J K Abraham   +14 more
doaj   +1 more source

Zinc finger and SCAN domain containing 1, ZSCAN1, is a novel stemness-related tumor suppressor and transcriptional repressor in breast cancer targeting TAZ

Frontiers in Oncology, 2023
IntroductionCancer stem cells (CSCs) targeted therapy holds the potential for improving cancer management; identification of stemness-related genes in CSCs is necessary for its development.MethodsThe Cancer Genome Atlas (TCGA) and the Molecular Taxonomy ...
Jian Chu, Yunzhe Li, Misi He, Hui Zhang, Lingling Yang, Muyao Yang, Jingshu Liu, Chenxi Cui, Liquan Hong, Xingchi Hu, Lei Zhou, Lei Zhou, Tangya Li, Changchun Li, Huiwen Fan, Guoqin Jiang, Tingyuan Lang, Tingyuan Lang   +17 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

METTL3-mediated m6A modification of LINC00857 enhances stemness and metastasis of ovarian cancer cells by activating the YAP-TEAD pathway

Scientific Reports
This study was designed to illustrate the mechanism underlying the up-regulation of LINC00857 expression and to identify novel molecular targets for the treatment of ovarian cancer (OC).
Xueke Lin, Yiting Hong, Shengjun You, Ping Li, Yuchun Lv, Jinyang Zheng, Pengming Sun   +6 more
doaj   +1 more source

The effect of multimedia interventions on the informed consent process for cataract surgery in rural South India

Indian Journal of Ophthalmology, 2014
Context: The provision of ocular surgical interventions for poorer, less educated populations is increasing as a result of increased globalization and outreach.
Abraar Karan, Prashanth Somasundaram, Haben Michael, Aryan Shayegani, Hylton Mayer   +4 more
doaj   +1 more source

Isolation of sphere-forming stem cells from the mouse inner ear

, 2009
The mammalian inner ear has very limited ability to regenerate lost sensory hair cells. This deficiency becomes apparent when hair cell loss leads to hearing loss as a result of either ototoxic insult or the aging process.
Oshima, Kazuo, Senn, Pascal, Stefan Heller, Pascal Senn, Heller, Stefan, Kazuo Oshima   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating the Effects of ONC206 Alone and in Combination with Cisplatin on Ovarian Cancer Cell Models

Current Issues in Molecular Biology
Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide, with high rates of disease relapse posing a significant therapeutic challenge. Consequently, there is an urgent need to develop novel treatments for OC.
Sara Mikhael, Rona Fayyad, Leen Abi Harfouch, Varun Vijay Prabhu, Hisham F. Bahmad, Wassim Abou-Kheir, Georges Daoud   +6 more
doaj   +1 more source

Corneal changes following collagen cross linking and simultaneous topography guided photoablation with collagen cross linking for keratoconus

Indian Journal of Ophthalmology, 2014
Purpose: To compare the outcome of Collagen cross-linking (CXL) with that following topography-guided customized ablation treatment (T-CAT) with simultaneous CXL in eyes with progressive keratoconus.
Prema Padmanabhan, Aishwaryah Radhakrishnan, Abinaya Priya Venkataraman, Nidhi Gupta, Bhaskar Srinivasan   +4 more
doaj   +1 more source