Results 41 to 50 of about 19,453 (266)
Circle, sphere, and drop packings [PDF]
We studied the geometrical and topological rules underlying the dispositions and the size distribution of non-overlapping, polydisperse circle-packings. We found that the size distribution of circles that densely cover a plane follows the power law: $N(R) \propto R^{-α}$.
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Structural similarity between dry and wet sphere packings
The mechanical properties of granular materials change significantly in the presence of a wetting liquid which creates capillary bridges between the particles. This results e.g.
Simon Weis +2 more
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Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
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Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Sphere packings in Euclidean space with forbidden distances
In this paper, we study the sphere packing problem in Euclidean space where we impose additional constraints on the separations of the center points. We prove that any sphere packing in dimension $48$ , with spheres of radii r, such that no two ...
Felipe Gonçalves, Guilherme Vedana
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A dichotomous search-based heuristic for the three-dimensional sphere packing problem
In this paper, the three-dimensional sphere packing problem is solved by using a dichotomous search-based heuristic. An instance of the problem is defined by a set of $ n $ unequal spheres and an object of fixed width and height and, unlimited length ...
Mhand Hifi, Labib Yousef
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Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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