Results 131 to 140 of about 643,248 (351)

Point-spread function engineering to reduce the impact of spherical aberration on 3D computational fluorescence microscopy imaging.

open access: yesOptics Express, 2011
Wavefront encoding (WFE) with different cubic phase mask designs was investigated in engineering 3D point-spread functions (PSF) to reduce their sensitivity to depth-induced spherical aberration (SA) which affects computational complexity in 3D ...
Shuai Yuan, C. Preza
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

X ray microscope assembly and alignment support and advanced x ray microscope design and analysis [PDF]

open access: yes
Considerable efforts have been devoted recently to the design, analysis, fabrication, and testing of spherical Schwarzschild microscopes for soft x ray application in microscopy and projection lithography.
Shealy, David L.
core   +1 more source

Инфракрасная гибридная линза с исправленной сферической аберрацией [PDF]

open access: yes, 2013
Запропоновано метод корекції сферичної аберації монохроматичної рефракційної лінзи проектуванням її як гібридної. В основі методу лежить рівняння, що дає можливість для гібридної лінзи отримати розрахункові довжину хвилі і фокусну відстань її ...
Kolobrodov, V. G.   +8 more
core  

Experimental Validation of Fourier-based Point Spread Function Models in the Presence of Spherical Aberration

open access: green, 2023
R. Holinirina Dina Miora   +5 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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