Results 111 to 120 of about 313,761 (243)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The effect of spherical aberration on the optical transfer function. [PDF]

open access: yes, 1955
Thesis (M.A.)--Boston UniversityThis paper discusses the behavior of the optical transfer function for an aberrated lens on an axis at several focus settings.
Parrent, George Burl
core   +1 more source

The results of spherical aberration of each IOL type.

open access: yes, 2016
The results of spherical aberration of each IOL type.
Tetsuro Oshika (308444)   +6 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

open access: yesMolecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Ocular higher-order aberrations and visual performance [PDF]

open access: yes, 2011
Since adaptive optics was first used to correct the monochromatic aberrations of the eye over a decade ago there has been considerable interest in correcting the ocular aberrations beyond defocus and astigmatism.
Young, Laura Kate, YOUNG, LAURA,KATE
core  

Ablation profiles for wavefront-guided correction of myopia and primary spherical aberration

open access: yes, 2002
To calculate ablation profiles for wavefront-guided correction of ametropia and primary spherical aberration. Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA.
Culbertson, William   +3 more
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

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