Results 51 to 60 of about 213,216 (285)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Unveiling the three-dimensional structure of galaxy clusters: resolving the discrepancy between X-ray and lensing masses

open access: yes, 2010
[Abridged] We present the first determination of the intrinsic three-dimensional shapes and the physical parameters of both dark matter (DM) and intra-cluster medium (ICM) in a triaxial galaxy cluster.
Andersson   +42 more
core   +7 more sources

FEM Analysis of Welded Spherical Joints’ Stiffness [PDF]

open access: yesAdvances in Engineering Research, 2014
Welded spherical joints’ stiffness has important influences on the strength and stability bearing capacity of reticulated shells. For complication of theoretical analysis and difficulty on experiments, the stiffness of welded spherical joints which is applied widely in the large-span reticulated shells, is analyzed and computed under the different ...
Xing WANG   +4 more
openaire   +1 more source

Self Organising Maps for Anatomical Joint Constraint [PDF]

open access: yes, 2011
The accurate simulation of anatomical joint models is becoming increasingly important for both realistic animation and diagnostic medical applications. Recent models have exploited unit quaternions to eliminate ingularities when modelling orientations ...
Dacey, Michael, Jenkins, Glenn
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

The Kinematic Investigation of the Stephenson-III Spherical Mechanism with a Spherical Slider Containing a Spherical Prismatic Pair

open access: yesApplied Sciences, 2023
Multi-loop spherical mechanisms are extremely beneficial for creating versatile mechanical devices, including robotic joints and surgical tools, since multi-loop spherical mechanisms possess unique capabilities to operate in spatial situations with ...
Jun Wang, Mingquan Yang, Yizhe Huang
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Spherical pipe joint delivers loads equally to mating flange [PDF]

open access: yes, 1966
Oxidizer inlet duct with a ball joint pipe fitting incorporating two spherical bearing races and balls in contact with centering cage springs transmits an evenly distributed load to the mating flange. This design should find application in piping systems
Pfleger, R. O.
core   +1 more source

Broadband Multizone Sound Rendering by Jointly Optimizing the Sound Pressure and Particle Velocity

open access: yes, 2017
In this paper, a recently proposed approach to multizone sound field synthesis, referred to as Joint Pressure and Velocity Matching (JPVM), is investigated analytically using a spherical harmonics representation of the sound field.
Buerger, Michael   +2 more
core   +1 more source

Primary stability of cementless threaded acetabular cups at first implantation and in the case of revision regarding micromotions as indicators [PDF]

open access: yes, 2012
The primary stability of cementless total hip endoprosthesis is of vital importance for proximate, long-term osteointegration. The extent of micromotions between implant and acetabulum is an indicator of primary stability.
Buerkner, Andreas   +6 more
core   +1 more source

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