Results 131 to 140 of about 20,351 (298)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Sparse Spherical Harmonic Component Selection for Gravity Field Modeling

Remote Sensing
Gravity field modeling with spherical harmonics is a fundamental task in physical geodesy. In conventional solutions, all spherical harmonic (SH) components below a prescribed maximum degree and order are typically retained, even though some components ...
Nijia Qian, Guobin Chang, Xun Zhang, Yong Feng, Dehu Yang   +4 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Matrix Coefficients with Minimal K-Types of the Spherical and Non-Spherical Principal Series Representations of SL(3, R)

, 2012
We compute the holonomic system of rank 6 for the radial part of the matrix coefficients of spherical and non-spherical principal series representations of SL(3, R).
Sono Keiju
core  

Geographic Location Encoding with Spherical Harmonics and Sinusoidal Representation Networks

Learning representations of geographical space is vital for any machine learning model that integrates geolocated data, spanning application domains such as remote sensing, ecology, or epidemiology.
Klemmer, Konstantin, Tuia, Devis, Rußwurm, Marc, Rolf, Esther, Zbinden, Robin   +4 more
core   +1 more source

Toward high throughput 3D virtual screening using spherical harmonic surface representations

, 2007
Searching chemical databases for possible drug leads is often one of the main activities conducted during the early stages of a drug development project. This article shows that spherical harmonic molecular shape representations provide a powerful way to
Hudson, Brian D., Ritchie, David, Ritchie, David W., Hudson, Brian, D., Mavridis, Lazaros   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Conversions between Parametric and Implicit Forms Using Polar/Spherical Coordinate Representations

, 2001
this paper, a new method for converting between parametric and implicit forms based on polar/spherical coordinate representations is introduced. c 2001 Academic Press Key Words: implicitization; parameterization; polar coordinates; spherical ...
Aytül Erçil, Cem Ünsalan
core  

Towers with Golden Orbs. Motif of Cupolaed Spires with Spherical Supports

Biuletyn Historii Sztuki
The article is devoted to the hitherto overlooked architectural motif of spherical supports in tower spires, observed in northern Europe since the early 17th century. Probably derived from the obelisk ball-based motif popular in iconography.
Zygmunt Łuniewicz
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source