Results 21 to 30 of about 5,242 (165)

Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

eLife, 2018
Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major ...
Nicole Toepfner, Christoph Herold, Oliver Otto, Philipp Rosendahl, Angela Jacobi, Martin Kräter, Julia Stächele, Leonhard Menschner, Maik Herbig, Laura Ciuffreda, Lisa Ranford-Cartwright, Michal Grzybek, Ünal Coskun, Elisabeth Reithuber, Geneviève Garriss, Peter Mellroth, Birgitta Henriques-Normark, Nicola Tregay, Meinolf Suttorp, Martin Bornhäuser, Edwin R Chilvers, Reinhard Berner, Jochen Guck   +22 more
doaj   +1 more source

Hereditary Spherocytosis With Liver Transplantation After Cirrhosis: A Case Report

Frontiers in Medicine, 2022
The clinical manifestations of hereditary spherocytosis are similar to those of various hemolytic anemias, which causes hereditary spherocytosis to be difficult to diagnose clinically.
Xueliang Yang, Wen Wang, Wanhu Fan, Lin Cai, Feng Ye, Shumei Lin, Xiaojing Liu   +6 more
doaj   +1 more source

PIEZO1 Hypomorphic Variants in Congenital Lymphatic Dysplasia Cause Shape and Hydration Alterations of Red Blood Cells

Frontiers in Physiology, 2019
PIEZO1 is a cation channel activated by mechanical force. It plays an important physiological role in several biological processes such as cardiovascular, renal, endothelial and hematopoietic systems. Two different diseases are associated with alteration
Immacolata Andolfo, Immacolata Andolfo, Gianluca De Rosa, Gianluca De Rosa, Edoardo Errichiello, Francesco Manna, Francesco Manna, Barbara Eleni Rosato, Barbara Eleni Rosato, Antonella Gambale, Antonella Gambale, Annalisa Vetro, Valeria Calcaterra, Gloria Pelizzo, Lucia De Franceschi, Orsetta Zuffardi, Roberta Russo, Roberta Russo, Achille Iolascon, Achille Iolascon   +19 more
doaj   +1 more source

IDENTIFICATION AND VERIFICATION OF HEREDITARY SPHEROCYTOSIS BY MEANS OF LABORATORY DIAGNOSIS

Педиатрическая фармакология, 2014
Aim. Hereditary spherocytosis (HS) is the most commonly encountered erythrocyte membranopathy. Frequency of occurrence of the disease makes one case per 2000−5000 newborns.
Yu. A. Prokhorova, E. E. Zueva, N. E. Sokolova, G. N. Salogub, V. I. Golubeva   +4 more
doaj   +1 more source

Anti-E Minor Blood Group Incompatibility and Hereditary Spherocytosis Associated Severe Hyperbilirubinemia: Neonatal Case Report

Forbes Tıp Dergisi, 2022
Neonatal jaundice is one of the most common clinical findings in the neonatal period. In neonatal pathological jaundice, the causes of hyperbilirubinemia caused by erythrocyte destruction should be considered and evaluated in terms of hemolytic jaundice.
Sema TANRIVERDİ, Sinem ATİK
doaj   +1 more source

Inherited Disorder of Hemoglobin: A Descriptive Study in Misan, Iraq, 2024 [PDF]

Journal of Medical and Life Science
Background: Inherited hemoglobin disorders represent a critical health challenge worldwide, These disorders encompass a range of genetic conditions affecting the structure or production of hemoglobin.
Thaer Al-Omary
doaj   +1 more source

Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?

Frontiers in Physiology, 2017
For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation.
Laura Hertz, Rick Huisjes, Esther Llaudet-Planas, Polina Petkova-Kirova, Asya Makhro, Jens G. Danielczok, Stephane Egee, Stephane Egee, Stephane Egee, Maria del Mar Mañú-Pereira, Richard van Wijk, Joan-Lluis Vives Corrons, Anna Bogdanova, Lars Kaestner, Lars Kaestner   +14 more
doaj   +1 more source

Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis

Haematologica, 2020
Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC).
Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P. Verhagen, Silvia Pignatelli, Minke A.E. Rab, Raymond M. Schiffelers, Elena Seiler, Wouter W. van Solinge, Joan-LLuis Vives Corrons, Lars Kaestner, Maria Mañú-Pereira, Anna Bogdanova, Richard van Wijk   +15 more
doaj   +1 more source

Intraoperative Cell-Saver Caused More Autologous Salvage Hemolysis in a Hereditary Spherocytosis Patient Than in a Normal Erythrocyte Patient

Frontiers in Physiology, 2022
Hereditary spherocytosis is a common red blood cell disease caused by an inherited red blood cell membrane defect, leading to a spherical shape and propensity for hemolysis.
Di Jin, Le Shen, Le Shen, Yuguang Huang, Yuguang Huang   +4 more
doaj   +1 more source

Hereditary spherocytosis: Retrospective evaluation of 65 children

The Turkish Journal of Pediatrics, 2018
Hereditary spherocytosis (HS) is a common cause of congenital hemolytic anemia in Caucasians and it could be diagnosed at any age. The aim of this study is to examine the demographic characteristics, clinical features and laboratory findings of children
Ali Güngör, Neşe Yaralı, Ali Fettah, İkbal Ok-Bozkaya, Namık Özbek, Abdurrahman Kara   +5 more
doaj   +1 more source