Results 1 to 10 of about 2,018 (241)
Ankyrins and neurological disease [PDF]
Current Opinion in Neurobiology, 2021 Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton.
Sharon R Stevens, Matthew N Rasband
exaly +5 more sources
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Timothy Jegla +2 more
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Ankyrins and Spectrins in Cardiovascular Biology and Disease
Frontiers in Physiology, 2017 Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Peter J Mohler, Mohler Peter J
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Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters [PDF]
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
doaj +2 more sources
eLife, 2021 Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in
Sharon R Stevens +10 more
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The toxins of vertically transmitted Spiroplasma [PDF]
Frontiers in Microbiology, 2023 Vertically transmitted (VT) microbial symbionts play a vital role in the evolution of their insect hosts. A longstanding question in symbiont research is what genes help promote long-term stability of vertically transmitted lifestyles.
Logan D. Moore, Matthew J. Ballinger
doaj +2 more sources
Ankyrins are dispensable for mechanotransduction by cochlear hair cells [PDF]
Hearing ResearchXufeng Qiu +2 more
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Ankrd31 in Sperm and Epididymal Integrity
Frontiers in Cell and Developmental Biology, 2021 Ankyrin proteins (ANKRD) are key mediators linking membrane and sub-membranous cytoskeletal proteins. Recent findings have highlighted a new role of ANKRD31 during spermatogenesis, elucidating its involvement in meiotic recombination and male germ cell ...
Francesco Manfrevola +13 more
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Frontiers in Cell and Developmental Biology, 2022 Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci +12 more
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Frontiers in Cell and Developmental Biology, 2021 Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan +2 more
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