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Ankyrins and neurological disease [PDF]
Current Opinion in Neurobiology, 2021 Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton.
Matthew Rasband, Sharon R Stevens
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Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters [PDF]
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
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Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Esteban Luna +2 more
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The toxins of vertically transmitted Spiroplasma [PDF]
Frontiers in Microbiology, 2023 Vertically transmitted (VT) microbial symbionts play a vital role in the evolution of their insect hosts. A longstanding question in symbiont research is what genes help promote long-term stability of vertically transmitted lifestyles.
Logan D. Moore, Matthew J. Ballinger
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Ankyrins and Spectrins in Cardiovascular Biology and Disease
Frontiers in Physiology, 2017 Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Peter Mohler, Mohler Peter J
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Ankyrins are dispensable for mechanotransduction by cochlear hair cells [PDF]
Hearing ResearchJonah Mittelstadt, Ulrich Mueller
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Ankyrin‐2 genetic variants: A case of Ankyrin‐B syndrome [PDF]
Annals of Noninvasive Electrocardiology, 2022 AbstractInherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin‐B or ankyrin‐2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to life‐threatening arrhythmias. In this case study, we report a typical ankyrin‐2 variant, in
Jin Song +2 more
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Ankrd31 in Sperm and Epididymal Integrity
Frontiers in Cell and Developmental Biology, 2021 Ankyrin proteins (ANKRD) are key mediators linking membrane and sub-membranous cytoskeletal proteins. Recent findings have highlighted a new role of ANKRD31 during spermatogenesis, elucidating its involvement in meiotic recombination and male germ cell ...
Francesco Manfrevola +13 more
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FEBS Letters, 2000 This review is focused on ankyrin which is a protein linker between the integral membrane proteins and spectrin‐based cytoskeleton. Structure and distribution of different ankyrin isoforms that are products of alternative‐spliced genes are described. Interaction of ankyrins with various membranes is considered.
Rubtsov, Alexander M, Lopina, Olga D
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Frontiers in Cell and Developmental Biology, 2022 Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci +12 more
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