Results 11 to 20 of about 1,875 (199)

Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels

eLife, 2021
Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in
Sharon R Stevens, Colleen M Longley, Yuki Ogawa, Lindsay H Teliska, Anithachristy S Arumanayagam, Supna Nair, Juan A Oses-Prieto, Alma L Burlingame, Matthew D Cykowski, Mingshan Xue, Matthew N Rasband   +10 more
doaj   +1 more source

Production of a common epitope specific anti-ankyrin monoclonal antibody

Journal of Associated Medical Sciences, 2022
Background: Ankyrin (Ank) is a protein family with crucial roles in retaining normal cellular physiology. In addition, ankyrin offers the potential as a non-antibody binder against various biomolecules.
On-anong Juntit, Suthinee Soponpong, Chaochetdhapada Putpim, Watchara Kasinrerk, Chatchai Tayapiwatana   +4 more
doaj   +1 more source

Poxviral Ankyrin Proteins [PDF]

Viruses, 2015
Multiple repeats of the ankyrin motif (ANK) are ubiquitous throughout the kingdoms of life but are absent from most viruses. The main exception to this is the poxvirus family, and specifically the chordopoxviruses, with ANK repeat proteins present in all but three species from separate genera.
Michael H. Herbert, Christopher J. Squire, Andrew A Mercer   +2 more
openaire   +3 more sources

Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization

Frontiers in Cell and Developmental Biology, 2021
Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan, Kelsey E. Murphy, Patricia F. Maness   +2 more
doaj   +1 more source

Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]

PLoS ONE, 2016
The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich, Gilbert W Moeckel, Lan Ji, Thomas Ardito, Jon S Morrow   +4 more
doaj   +1 more source

Genomic and transcriptomic analyses provide insights into valuable fatty acid biosynthesis and environmental adaptation of yellowhorn

Frontiers in Plant Science, 2022
Yellowhorn (Xanthoceras sorbifolium) is an oil-bearing tree species growing naturally in poor soil. The kernel of yellowhorn contains valuable fatty acids like nervonic acid.
Qiang Liang, Jian Ning Liu, Hongcheng Fang, Yuhui Dong, Changxi Wang, Yan Bao, Wenrui Hou, Rui Zhou, Xinmei Ma, Shasha Gai, Lichang Wang, Shouke Li, Ke Qiang Yang, Ke Qiang Yang, Ke Qiang Yang, Ya Lin Sang, Ya Lin Sang, Ya Lin Sang   +17 more
doaj   +1 more source

Performance of Affinity-Improved DARPin Targeting HIV Capsid Domain in Interference of Viral Progeny Production

Biomolecules, 2021
Previously, a designed ankyrin repeat protein, AnkGAG1D4, was generated for intracellular targeting of the HIV-1 capsid domain. The efficiency was satisfactory in interfering with the HIV assembly process.
Kanokporn Sornsuwan, Weeraya Thongkhum, Thanathat Pamonsupornwichit, Tanawan Samleerat Carraway, Suthinee Soponpong, Supachai Sakkhachornphop, Chatchai Tayapiwatana, Umpa Yasamut   +7 more
doaj   +1 more source

Mechanical Anisotropy of Ankyrin Repeats [PDF]

Biophysical Journal, 2012
Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W, Zeng, X, Rotolo, K, Yang, M, Schofield, C, Bennett, V, Yang, W, Marszalek, P   +7 more
openaire   +3 more sources

Sequence and Structure-Based Analyses of Human Ankyrin Repeats

Molecules, 2022
Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating units.
Broto Chakrabarty, Nita Parekh
doaj   +1 more source

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions

eLife, 2017
Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen, Jianchao Li, Chao Wang, Zhiyi Wei, Mingjie Zhang   +4 more
doaj   +1 more source