Results 11 to 20 of about 2,018 (241)
FEBS Letters, 2000 This review is focused on ankyrin which is a protein linker between the integral membrane proteins and spectrin‐based cytoskeleton. Structure and distribution of different ankyrin isoforms that are products of alternative‐spliced genes are described. Interaction of ankyrins with various membranes is considered.
Rubtsov, Alexander M, Lopina, Olga D
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eLife, 2017 Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen +4 more
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Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein [PDF]
Retrovirology, 2012 Background Ankyrins are cellular mediators of a number of essential protein-protein interactions. Unlike intrabodies, ankyrins are composed of highly structured repeat modules characterized by disulfide bridge-independent folding.
Nangola Sawitree +8 more
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Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]
PLoS ONE, 2016 The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich +4 more
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The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability [PDF]
Frontiers in Cell and Developmental Biology, 2019 The structural integrity of synaptic connections critically depends on the interaction between synaptic cell adhesion molecules (CAMs) and the underlying actin and microtubule cytoskeleton.
Tobias Weber +3 more
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Evolution in Action: Giant Ankyrins Awake [PDF]
Developmental Cell, 2015 Reporting in Developmental Cell, Stephan et al. (2015) demonstrate critical axonal and presynaptic functions from acquisition of an enormous exon by the Drosophila ank2 gene. They propose that highly elongated ank2-XL molecules, associated with the plasma membrane through spectrin and ank2-L, extend deep into the axoplasm to promote microtubule ...
Bennett, Vann, Walder, Kathryn
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Obscurin regulates ankyrin macromolecular complex formation. [PDF]
J Mol Cell Cardiol, 2022 Obscurin is a large scaffolding protein in striated muscle that maintains sarcolemmal integrity and aligns the sarcoplasmic reticulum with the underlying contractile machinery.
Subramaniam J, Yamankurt G, Cunha SR.
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Ankyrin‐2 genetic variants: A case of Ankyrin‐B syndrome [PDF]
Annals of Noninvasive Electrocardiology, 2022 AbstractInherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin‐B or ankyrin‐2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to life‐threatening arrhythmias. In this case study, we report a typical ankyrin‐2 variant, in
Jin Song +2 more
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Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. [PDF]
Curr Biol, 2021 Skeletal muscle contraction depends on activation of clustered acetylcholine receptors (AchRs) and muscle-specific Na(+) channels (Nav1.4). Some Nav1.4 channels are highly enriched at the neuromuscular junction (NMJ) and their clustering is thought to be
Zhang C +8 more
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Poxviral Ankyrin Proteins [PDF]
Viruses, 2015 Multiple repeats of the ankyrin motif (ANK) are ubiquitous throughout the kingdoms of life but are absent from most viruses. The main exception to this is the poxvirus family, and specifically the chordopoxviruses, with ANK repeat proteins present in all but three species from separate genera.
Michael H. Herbert +2 more
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