Results 1 to 10 of about 42,034 (274)

Sequence and Structure-Based Analyses of Human Ankyrin Repeats

Molecules, 2022
Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating units.
Broto Chakrabarty, Nita Parekh, Parekh Nita   +2 more
exaly   +4 more sources

Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons

Frontiers in Physiology, 2023
Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons.
Paul M Jenkins
exaly   +3 more sources

The varied functions of the giant muscle scaffold protein obscurin [PDF]

Frontiers in Cell and Developmental Biology
Obscurin is a giant protein encoded by the OBSCN gene in human myocytes, known for its roles in sarcomere organization, elasticity, stretch response, and myofibrillogenesis.
James Novac Di Paola, Frieder Schöck
doaj   +2 more sources

Wolbachia uses ankyrin repeats to target specific fly proteins [PDF]

mBio
Arthropods, the most diverse phylum on Earth, are hosts to a plethora of bacterial parasites that secrete various effectors of unknown function during infection. The most prevalent of these is the intracellular bacterium Wolbachia pipientis.
William Hamilton, Erin Hardy, Sergio López-Madrigal, Melissa Phelps, MaryAnn Martin, Irene Newton   +5 more
doaj   +2 more sources

Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function

Biomolecules, 2020
Ankyrin-B (encoded by ANK2), originally identified as a key cytoskeletal-associated protein in the brain, is highly expressed in the heart and plays critical roles in cardiac physiology and cell biology.
Mona El Refaey, Sara N Koenig, Peter J Mohler   +2 more
exaly   +3 more sources

The Diversity and Evolution of Wolbachia Ankyrin Repeat Domain Genes [PDF]

PLoS ONE, 2013
Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species.
Stefanos Siozios, Panagiotis Ioannidis, Lisa Klasson   +2 more
exaly   +2 more sources

Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]

Biomolecules
The axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu, Yanyan Yu, Zhuqian Jiang, Yoshinori Otani, Masashi Fujitani   +4 more
doaj   +2 more sources

Specific Interaction of DARPin with HIV-1 CA_NTD Disturbs the Distribution of Gag, RNA Packaging, and Tetraspanin Remodelling in the Membrane

Viruses, 2022
A designed repeat scaffold protein (AnkGAG1D4) recognizing the human immunodeficiency virus-1 (HIV-1) capsid (CA) was formerly established with antiviral assembly. Here, we investigated the molecular mechanism of AnkGAG1D4 function during the late stages
Sutpirat Moonmuang, Rawiwan Maniratanachote, Paninee Chetprayoon, Kanokporn Sornsuwan, Weeraya Thongkum, Koollawat Chupradit, Chatchai Tayapiwatana   +6 more
doaj   +1 more source

Molecular Mechanisms of L1 and NCAM Adhesion Molecules in Synaptic Pruning, Plasticity, and Stabilization

Frontiers in Cell and Developmental Biology, 2021
Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan, Kelsey E. Murphy, Patricia F. Maness   +2 more
doaj   +1 more source

Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A

eLife, 2021
Variants in the high confident autism spectrum disorder (ASD) gene ANK2 target both ubiquitously expressed 220 kDa ankyrin-B and neurospecific 440 kDa ankyrin-B (AnkB440) isoforms.
Blake A Creighton, Simone Afriyie, Deepa Ajit, Cristine R Casingal, Kayleigh M Voos, Joan Reger, April M Burch, Eric Dyne, Julia Bay, Jeffrey K Huang, ES Anton, Meng-Meng Fu, Damaris N Lorenzo   +12 more
doaj   +1 more source