Ankyrin-B is lipid-modified by S-palmitoylation to promote dendritic membrane scaffolding of voltage-gated sodium channel NaV1.2 in neurons [PDF]
Frontiers in Physiology, 2023 Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons.
Paul M Jenkins
exaly +6 more sources
Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function [PDF]
Biomolecules, 2020 Ankyrin-B (encoded by ANK2), originally identified as a key cytoskeletal-associated protein in the brain, is highly expressed in the heart and plays critical roles in cardiac physiology and cell biology.
Mona El Refaey +2 more
exaly +5 more sources
Ankyrin‐2 genetic variants: A case of Ankyrin‐B syndrome [PDF]
Annals of Noninvasive Electrocardiology, 2022 Inherited cardiac arrhythmias (ICA) have become one of the leading causes of sudden cardiac death in people under 40 years old. Variants in the ankyrin‐B or ankyrin‐2 genes will result in several cardiac arrhythmias ranging from sinus node dysfunction to
Jin Song +2 more
doaj +5 more sources
Ankyrin B and Ankyrin B variants differentially modulate intracellular and surface Cav2.1 levels [PDF]
Molecular Brain, 2019 Ankyrin B (AnkB) is an adaptor and scaffold for motor proteins and various ion channels that is ubiquitously expressed, including in the brain. AnkB has been associated with neurological disorders such as epilepsy and autism spectrum disorder, but ...
Catherine S. W. Choi +5 more
doaj +7 more sources
Mechanisms underlying the role of ankyrin-B in cardiac and neurological health and disease [PDF]
Frontiers in Cardiovascular Medicine, 2022 The ANK2 gene encodes for ankyrin-B (ANKB), one of 3 members of the ankyrin family of proteins, whose name is derived from the Greek word for anchor. ANKB was originally identified in the brain (B denotes “brain”) but has become most widely known for its
Nicole S. York +7 more
doaj +4 more sources
The evolving role of ankyrin-B in cardiovascular disease [PDF]
Heart Rhythm, 2017 Over the past decade, ankyrin-B has been identified as a prominent player in cardiac physiology. Ankyrin-B has a multitude of functions, with roles in expression, localization, and regulation of proteins critical for cardiac excitability, cytoskeletal integrity, and signaling.
Sara N Koenig, Peter J Mohler
exaly +5 more sources
PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B [PDF]
Nature Communications, 2021 Mitochondria in skeletal muscle have distinct localization and properties through unclear mechanisms. Here, the authors use complexome profiling and immunoprecipitations to identify PERM1 as a MICOS-MIB complex interactor that also binds ankyrin B ...
Theresa Bock +11 more
doaj +7 more sources
Regulation of perisomatic synapses from cholecystokinin basket interneurons through NrCAM and Ankyrin B [PDF]
Current Research in NeurobiologyThe perisomatic region of cortical pyramidal neurons (PNs) integrates local and long-range inputs and regulates firing. This domain receives GABAergic inputs from cholecystokinin (CCK)- and Parvalbumin (PV)-expressing basket cells (BCs) but how synaptic ...
Erik N. Oldre +3 more
doaj +5 more sources
T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B [PDF]
Molecular Brain, 2018 This study describes the functional interaction between the Cav3.1 and Cav3.2 T-type calcium channels and cytoskeletal spectrin (α/β) and ankyrin B proteins.
Agustin Garcia-Caballero +10 more
doaj +6 more sources
A Single Divergent Exon Inhibits Ankyrin-B Association with the Plasma Membrane [PDF]
Journal of Biological Chemistry, 2013 Vertebrate ankyrin-B and ankyrin-G exhibit divergent subcellular localization and function despite their high sequence and structural similarity and common origin from a single ancestral gene at the onset of chordate evolution. Previous studies of ankyrin family diversity have focused on the C-terminal regulatory domain.
Vann Bennett
exaly +5 more sources