Results 41 to 50 of about 9,634,082 (235)
Regulation of the ankyrin-B-based targeting pathway following myocardial infarction [PDF]
Cardiovascular Research, 2008 Ion channel reorganization is a critical step in the pro-arrhythmogenic remodelling process that occurs in heart disease. Ankyrin-B (AnkB) is required for targeting and stabilizing ion channels, exchangers, and pumps. Despite a wealth of knowledge implicating the importance of AnkB in human cardiovascular physiology, nothing is known regarding the role
Thomas J, Hund +5 more
openaire +2 more sources
Ankyrins and Spectrins in Cardiovascular Biology and Disease
Frontiers in Physiology, 2017 Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Mona M. El Refaey +4 more
doaj +1 more source
Ankyrin‐B is a critical determinant of vasomotor function
The FASEB Journal, 2010 Ankyrin B (AnkB) plays an important role in normal cardiac and neuronal function by linking membrane proteins to the cytoskeleton. Little is known, however, about the role of AnkB in the vasculature. Thus, we studied vasomotor function in aortas from wild‐type mice (AnkB
Shane R Cunha +2 more
openaire +1 more source
The Role of BANK1 in B Cell Signaling and Disease
Cells, 2021 The B cell scaffold protein with ankyrin repeats (BANK1) is expressed primarily in B cells and with multiple but discrete roles in B cell signaling, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling.
Gonzalo Gómez Hernández +2 more
doaj +1 more source
Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. [PDF]
J Clin Invest, 2015 Rare functional variants of ankyrin-B have been implicated in human disease, including hereditary cardiac arrhythmia and type 2 diabetes (T2D). Here, we developed murine models to evaluate the metabolic consequences of these alterations in vivo ...
Lorenzo DN +8 more
europepmc +2 more sources
Ankyrin-B Binds Disparate Proteins to Keep Calcium Flowing in the Heart
PLoS Biology, 2005 doaj +3 more sources
Virology Journal, 2011 Background The carboxyl terminal of Epstein-Barr virus (EBV) ZEBRA protein (also termed BZLF-1 encoded replication protein Zta or ZEBRA) binds to both NF-κB and p53. The authors have previously suggested that this interaction results from an ankyrin-like
Ghoda Lucy Y +3 more
doaj +1 more source
Alternative splicing: A key mechanism for ankyrin-B functional diversity? [PDF]
Journal of Molecular and Cellular Cardiology, 2008 Ankyrin is a family of adaptor proteins encoded by three genes, ANK1, ANK2 and ANK3 (also known as ankyrin-R, ankyrin-B and ankyrin-G, respectively) [1]. The ankyrins serve to link specific membrane proteins to the cellular cytoskeleton and help membrane proteins remain stably positioned in the correct location within the cell. The ankyrins contain 24 “
Ralph J. van Oort +3 more
openaire +1 more source
, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
core +1 more source
Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis [PDF]
, 1997 The characteristic shapes and positions of each individual body muscle are established during the process of muscle morphogenesis in response to patterning information from the surrounding mesenchyme. Throughout muscle morphogenesis, primary myotubes are
Arber, S. +5 more
core +1 more source