Results 31 to 40 of about 34,414 (193)
The Ankyrin-B C-terminal Domain Determines Activity of Ankyrin-B/G Chimeras in Rescue of Abnormal Inositol 1,4,5-Trisphosphate and Ryanodine Receptor Distribution in Ankyrin-B (−/−) Neonatal Cardiomyocytes [PDF]
Journal of Biological Chemistry, 2002 Ankyrins are a closely related family of membrane adaptor proteins that are believed to participate in targeting diverse membrane proteins to specialized domains in the plasma membrane and endoplasmic reticulum. This study addresses the question of how individual ankyrin isoforms achieve functional specificity when co-expressed in the same cell ...
Peter J, Mohler +2 more
openaire +2 more sources
Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. [PDF]
PLoS ONE, 2007 Here we report the unexpected finding that specific human ANK2 variants represent a new example of balanced human variants. The prevalence of certain ANK2 (encodes ankyrin-B) variants range from 2 percent of European individuals to 8 percent in ...
Peter J Mohler +8 more
doaj +1 more source
PLoS Biology, 2005 We report identification of an ankyrin-B-based macromolecular complex of Na/K ATPase (alpha 1 and alpha 2 isoforms), Na/Ca exchanger 1, and InsP3 receptor that is localized in cardiomyocyte T-tubules in discrete microdomains distinct from classic ...
Peter J Mohler +2 more
doaj +2 more sources
Frontiers in Neuroanatomy, 2023 A novel function for the L1 cell adhesion molecule, which binds the actin adaptor protein Ankyrin was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex.
Kelsey E. Murphy +17 more
doaj +1 more source
Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]
PLoS ONE, 2016 The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich +4 more
doaj +1 more source
Cell Reports, 2023 Summary: Rare genetic variants in ANK2, which encodes ankyrin-B, are associated with neurodevelopmental disorders (NDDs); however, their pathogenesis is poorly understood.
Sehyoun Yoon +7 more
doaj +1 more source
A cardiac arrhythmia syndrome caused by loss of ankyrin-B function [PDF]
Proceedings of the National Academy of Sciences, 2004 220-kDa ankyrin-B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (Ins P 3 ) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.
MOHLER P. +8 more
openaire +2 more sources
Ankyrin-B Targets β2-Spectrin to an Intracellular Compartment in Neonatal Cardiomyocytes [PDF]
Journal of Biological Chemistry, 2004 Ankyrin-B is a spectrin-binding protein that is required for localization of inositol 1,4,5-trisphosphate receptor and ryanodine receptor in neonatal cardiomyocytes. This work addresses the interaction between ankyrin-B and beta(2)-spectrin in these cells. Ankyrin-B and beta(2)-spectrin are colocalized in an intracellular striated compartment overlying
Peter J, Mohler +2 more
openaire +2 more sources
Regulation of the ankyrin-B-based targeting pathway following myocardial infarction [PDF]
Cardiovascular Research, 2008 Ion channel reorganization is a critical step in the pro-arrhythmogenic remodelling process that occurs in heart disease. Ankyrin-B (AnkB) is required for targeting and stabilizing ion channels, exchangers, and pumps. Despite a wealth of knowledge implicating the importance of AnkB in human cardiovascular physiology, nothing is known regarding the role
Thomas J, Hund +5 more
openaire +2 more sources
Ankyrins and Spectrins in Cardiovascular Biology and Disease
Frontiers in Physiology, 2017 Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Mona M. El Refaey +4 more
doaj +1 more source