Results 21 to 30 of about 34,414 (193)

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting. [PDF]

J Biol Chem, 2014
N-type and P/Q-type calcium channels are documented players in the regulation of synaptic function; however, the mechanisms underlying their expression and cellular targeting are poorly understood. Ankyrin polypeptides are essential for normal integral membrane protein expression in a number of cell types, including neurons, cardiomyocytes, epithelia ...
Kline CF, Scott J, Curran J, Hund TJ, Mohler PJ.   +4 more
europepmc   +4 more sources

Identification and characterization of two ankyrin-B isoforms in mammalian heart. [PDF]

Cardiovasc Res, 2015
Excitation-contraction coupling in cardiomyocytes requires the proper targeting and retention of membrane proteins to unique domains by adaptor proteins like ankyrin-B. While ankyrin-B has been shown to interact with a variety of membrane and structural proteins located at different subcellular domains in cardiomyocytes, what regulates the specificity ...
Wu HC, Yamankurt G, Luo J, Subramaniam J, Hashmi SS, Hu H, Cunha SR.   +6 more
europepmc   +4 more sources

Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart [PDF]

Journal of Biological Chemistry, 2010
Ankyrin polypeptides are critical for normal membrane protein expression in diverse cell types, including neurons, myocytes, epithelia, and erythrocytes. Ankyrin dysfunction results in defects in membrane expression of ankyrin-binding partners (including ion channels, transporters, and cell adhesion molecules), resulting in aberrant cellular function ...
Mark E Anderson, Thomas Hund, Crystal F Kline   +2 more
exaly   +3 more sources

Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics and clarity.

J Cell Sci
ABSTRACT Summary Statement This study illustrates a vital role for ankyrin-B in lens architecture, growth and function through its involvement in membrane protein and spectrin-actin cytoskeletal organization and stability The transparent ocular lens is essential for vision by ...
Maddala R, Allen A, Skiba NP, Rao PV.
europepmc   +4 more sources

Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes [PDF]

eLife, 2016
Endosomal membrane trafficking requires coordination between phosphoinositide lipids, Rab GTPases, and microtubule-based motors to dynamically determine endosome identity and promote long-range organelle transport.
Fangfei Qu, Damaris N Lorenzo, Samantha J King, Rebecca Brooks, James E Bear, Vann Bennett   +5 more
doaj   +2 more sources

A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. [PDF]

J Cell Biol, 2014
Axon growth requires long-range transport of organelles, but how these cargoes recruit their motors and how their traffic is regulated are not fully resolved. In this paper, we identify a new pathway based on the class III PI3-kinase (PIK3C3), ankyrin-B (AnkB), and dynactin, which promotes fast axonal transport of synaptic vesicles, mitochondria ...
Lorenzo DN, Badea A, Davis J, Hostettler J, He J, Zhong G, Zhuang X, Bennett V.   +7 more
europepmc   +6 more sources

A Novel Mechanism for Human Cardiac Ankyrin-B Syndrome due to Reciprocal Chromosomal Translocation. [PDF]

Heart Lung Circ, 2017
Cardiac rhythm abnormalities are a leading cause of morbidity and mortality in developed countries. Loss-of-function variants in the ANK2 gene can cause a variety of cardiac rhythm abnormalities including sinus node dysfunction, atrial fibrillation and ventricular arrhythmias (called the "ankyrin-B syndrome").
Huq AJ, Pertile MD, Davis AM, Landon H, James PA, Kline CF, Vohra J, Mohler PJ, Delatycki MB.   +8 more
europepmc   +4 more sources

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. [PDF]

Heart Rhythm, 2012
Cardiovascular disease is a leading cause of death worldwide. Arrhythmias are associated with significant morbidity and mortality related to cardiovascular disease. Recent work illustrates that many cardiac arrhythmias are initiated by a pathologic imbalance between kinase and phosphatase activities in excitable cardiomyocytes.To test the relationship ...
DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ.   +12 more
europepmc   +4 more sources

Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters

Channels, 2022
The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
doaj   +1 more source

Ankyrin-B Defects [PDF]

Circulation: Cardiovascular Genetics, 2017
One of the joys of a life in research is watching a prepared and inquisitive mind meet an unexpected finding, seemingly mundane, but opening new possibilities. So it is with the article by Swayne et al1 in this issue, who describe a novel ANK2 mutation associated with a prolonged QT interval in a population already enriched for a KCNQ1 mutation causing
Henry, Duff, Robert S, Sheldon
openaire   +2 more sources