Results 21 to 30 of about 9,634,082 (235)
Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions [PDF]
eLife, 2017 Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen +4 more
doaj +2 more sources
A Cantú syndrome mutation produces dual effects on KATP channels by disrupting ankyrin B regulation. [PDF]
J Gen Physiol, 2023 ATP-sensitive potassium (KATP) channels composed of Kir6.x and sulfonylurea receptor (SURs) subunits couple cellular metabolism to electrical activity. Cantú syndrome (CS) is a rare disease caused by mutations in the genes encoding Kir6.1 (KCNJ8) and SUR2A (ABCC9) that produce KATP channel hyperactivity due to a reduced channel block by physiological ...
Crespo-García T +10 more
europepmc +3 more sources
Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting. [PDF]
J Biol Chem, 2014 N-type and P/Q-type calcium channels are documented players in the regulation of synaptic function; however, the mechanisms underlying their expression and cellular targeting are poorly understood. Ankyrin polypeptides are essential for normal integral membrane protein expression in a number of cell types, including neurons, cardiomyocytes, epithelia ...
Kline CF +4 more
europepmc +4 more sources
Ankyrin-B protein in heart failure: identification of a new component of metazoan cardioprotection. [PDF]
J Biol Chem, 2012 Ankyrins (ankyrin-R, -B, and -G) are adapter proteins linked with defects in metazoan physiology. Ankyrin-B (encoded by ANK2) loss-of-function mutations are directly associated with human cardiovascular phenotypes including sinus node disease, atrial fibrillation, ventricular tachycardia, and sudden cardiac death.
Kashef F +10 more
europepmc +4 more sources
Identification and characterization of two ankyrin-B isoforms in mammalian heart. [PDF]
Cardiovasc Res, 2015 Excitation-contraction coupling in cardiomyocytes requires the proper targeting and retention of membrane proteins to unique domains by adaptor proteins like ankyrin-B. While ankyrin-B has been shown to interact with a variety of membrane and structural proteins located at different subcellular domains in cardiomyocytes, what regulates the specificity ...
Wu HC +6 more
europepmc +4 more sources
Ankyrin-B Regulates Kir6.2 Membrane Expression and Function in Heart [PDF]
Journal of Biological Chemistry, 2010 Ankyrin polypeptides are critical for normal membrane protein expression in diverse cell types, including neurons, myocytes, epithelia, and erythrocytes. Ankyrin dysfunction results in defects in membrane expression of ankyrin-binding partners (including ion channels, transporters, and cell adhesion molecules), resulting in aberrant cellular function ...
Jingdong Li +2 more
exaly +3 more sources
J Cell SciABSTRACT Summary Statement This study illustrates a vital role for ankyrin-B in lens architecture, growth and function through its involvement in membrane protein and spectrin-actin cytoskeletal organization and stability The transparent ocular lens is essential for vision by ...
Maddala R, Allen A, Skiba NP, Rao PV.
europepmc +4 more sources
Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes [PDF]
eLife, 2016 Endosomal membrane trafficking requires coordination between phosphoinositide lipids, Rab GTPases, and microtubule-based motors to dynamically determine endosome identity and promote long-range organelle transport.
Fangfei Qu +5 more
doaj +2 more sources
A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. [PDF]
J Cell Biol, 2014 Axon growth requires long-range transport of organelles, but how these cargoes recruit their motors and how their traffic is regulated are not fully resolved. In this paper, we identify a new pathway based on the class III PI3-kinase (PIK3C3), ankyrin-B (AnkB), and dynactin, which promotes fast axonal transport of synaptic vesicles, mitochondria ...
Lorenzo DN +7 more
europepmc +6 more sources
Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome
American Journal of Physiology-Heart and Circulatory Physiology, 2010 Normal cardiac excitability depends on the coordinated activity of specific ion channels and transporters within specialized domains at the plasma membrane and sarcoplasmic reticulum. Ion channel dysfunction due to congenital or acquired defects has been linked to human cardiac arrhythmia. More recently, defects in ion channel-associated proteins have
Roseanne M, Wolf +4 more
openaire +4 more sources