Current diagnostic approach and screening methods for hereditary spherocytosis
Thalassemia Reports, 2013 The plasma membrane of the erythrocyte accounts for all of its antigenic, transport, and mechanical characteristics, particularly its ability to undergo large passive deformations during repeated passage through the narrow capillaries of the ...
Paola Bianchi
doaj +1 more source
Ankyrin-B Reduction Enhances Calcium Sparks via CamkII [PDF]
Biophysical Journal, 2014 Ankyrin-B (AnkB) is a scaffolding protein that tethers to the cytoskeleton and targets select membrane proteins, including the Na+/Ca2+ exchanger and Na+/K+-ATPase, key regulators of cardiac contractility and arrhythmogenesis. Humans with loss-of-function mutations in AnkB and mice heterozygous for a null mutation in AnkB (AnkB+/- mice) display a ...
Galice, Samuel, Despa, Sanda
openaire +1 more source
Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
, 2011 Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...
core +1 more source
M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]
, 2009 Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Camus-Bouclainville, Christelle +10 more
core +1 more source
Ankyrin B and ankyrin G expression in cortex and medulla.
, 2016 (A&B) Immunofluorescent micrographs of ankyrin and α1-Na,K-ATPase in renal cortex and medulla. Both ankyrin B and G are found on both apical and basolateral membrane of tubule cells.
Michael C. Stankewich (842238) +4 more
core +1 more source
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling. [PDF]
PLoS ONE, 2013 The B cell adaptor protein with ankyrin repeats (BANK1) and the B lymphoid tyrosine kinase (BLK) have been genetically associated with autoimmunity. The proteins of these genes interact physically and work in concert during B-cell signaling.
Manuel Bernal-Quirós +3 more
doaj +1 more source
Developmental mechanism of the periodic membrane skeleton in axons
eLife, 2014 Actin, spectrin, and associated molecules form a periodic sub-membrane lattice structure in axons. How this membrane skeleton is developed and why it preferentially forms in axons are unknown.
Guisheng Zhong +6 more
doaj +1 more source
Ankyrin-B Is Required for Intracellular Sorting of Structurally Diverse Ca2+ Homeostasis Proteins [PDF]
The Journal of Cell Biology, 1999 This report describes a congenital myopathy and major loss of thymic lymphocytes in ankyrin-B (−/−) mice as well as dramatic alterations in intracellular localization of key components of the Ca2+ homeostasis machinery in ankyrin-B (−/−) striated muscle and thymus.
S, Tuvia +4 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source